Advanced

Risk Factors for Stroke in Subjects With Normal Blood Pressure. A Prospective Cohort Study.

Li, Cairu LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Berglund, Göran LU and Janzon, Lars LU (2005) In Stroke: a journal of cerebral circulation 36(2). p.234-238
Abstract
Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.



Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.



Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were... (More)
Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.



Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.



Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke.



Conclusion— In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
risk factors, stroke, blood pressure
in
Stroke: a journal of cerebral circulation
volume
36
issue
2
pages
234 - 238
publisher
American Heart Association
external identifiers
  • wos:000226507600029
  • pmid:15618439
  • scopus:12844275885
ISSN
1524-4628
DOI
10.1161/01.STR.0000152328.66493.0a
language
English
LU publication?
yes
id
6edac589-ed47-4664-863e-802832230fbb (old id 131847)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15618439&dopt=Abstract
date added to LUP
2007-07-25 12:45:17
date last changed
2017-10-22 04:44:07
@article{6edac589-ed47-4664-863e-802832230fbb,
  abstract     = {Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.<br/><br>
<br/><br>
Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP &lt;140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.<br/><br>
<br/><br>
Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke.<br/><br>
<br/><br>
Conclusion— In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke.},
  author       = {Li, Cairu and Engström, Gunnar and Hedblad, Bo and Berglund, Göran and Janzon, Lars},
  issn         = {1524-4628},
  keyword      = {risk factors,stroke,blood pressure},
  language     = {eng},
  number       = {2},
  pages        = {234--238},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Risk Factors for Stroke in Subjects With Normal Blood Pressure. A Prospective Cohort Study.},
  url          = {http://dx.doi.org/10.1161/01.STR.0000152328.66493.0a},
  volume       = {36},
  year         = {2005},
}