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Host-pathogen interactions in Streptococcus pyogenes infections, with special reference to puerperal fever and a comment on vaccine development.

Areschoug, Thomas LU ; Carlsson, Fredric LU ; Stålhammar-Carlemalm, Margaretha LU and Lindahl, Gunnar LU (2004) In Vaccine 22 Suppl 1(Suppl 1). p.9-14
Abstract
Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively studied virulence factor of S. pyogenes is the surface M protein, which inhibits phagocytosis and shows antigenic variation. Recent data indicate that many M proteins confer phagocytosis resistance because the variable N-terminal region has non-overlapping sites that specifically bind two components of the human immune system, the complement... (More)
Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively studied virulence factor of S. pyogenes is the surface M protein, which inhibits phagocytosis and shows antigenic variation. Recent data indicate that many M proteins confer phagocytosis resistance because the variable N-terminal region has non-overlapping sites that specifically bind two components of the human immune system, the complement inhibitor C4b-binding protein (C4BP) and IgA-Fc. Concerning puerperal fever, molecular and epidemiological analysis suggests that the S. pyogenes surface protein R28 may have played a pathogenetic role in these epidemics. This article summarizes the properties of M protein and the R28 protein and considers a potential problem encountered in connection with the use of animal models for vaccine development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C4b-binding protein, Group A streptococcus, Puerperal fever, Vaccines, IgA-Fc
in
Vaccine
volume
22 Suppl 1
issue
Suppl 1
pages
9 - 14
publisher
Elsevier
external identifiers
  • wos:000226100200003
  • scopus:9644252896
ISSN
1873-2518
DOI
10.1016/j.vaccine.2004.08.010
language
English
LU publication?
yes
id
001c7563-551b-4b59-b132-1a8fe5d86b9d (old id 132186)
date added to LUP
2007-07-09 15:06:50
date last changed
2017-06-25 03:28:12
@article{001c7563-551b-4b59-b132-1a8fe5d86b9d,
  abstract     = {Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively studied virulence factor of S. pyogenes is the surface M protein, which inhibits phagocytosis and shows antigenic variation. Recent data indicate that many M proteins confer phagocytosis resistance because the variable N-terminal region has non-overlapping sites that specifically bind two components of the human immune system, the complement inhibitor C4b-binding protein (C4BP) and IgA-Fc. Concerning puerperal fever, molecular and epidemiological analysis suggests that the S. pyogenes surface protein R28 may have played a pathogenetic role in these epidemics. This article summarizes the properties of M protein and the R28 protein and considers a potential problem encountered in connection with the use of animal models for vaccine development.},
  author       = {Areschoug, Thomas and Carlsson, Fredric and Stålhammar-Carlemalm, Margaretha and Lindahl, Gunnar},
  issn         = {1873-2518},
  keyword      = {C4b-binding protein,Group A streptococcus,Puerperal fever,Vaccines,IgA-Fc},
  language     = {eng},
  number       = {Suppl 1},
  pages        = {9--14},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Host-pathogen interactions in Streptococcus pyogenes infections, with special reference to puerperal fever and a comment on vaccine development.},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2004.08.010},
  volume       = {22 Suppl 1},
  year         = {2004},
}