Host-pathogen interactions in Streptococcus pyogenes infections, with special reference to puerperal fever and a comment on vaccine development.
(2004) In Vaccine 22 Suppl 1(Suppl 1). p.9-14- Abstract
- Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively studied virulence factor of S. pyogenes is the surface M protein, which inhibits phagocytosis and shows antigenic variation. Recent data indicate that many M proteins confer phagocytosis resistance because the variable N-terminal region has non-overlapping sites that specifically bind two components of the human immune system, the complement... (More)
- Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively studied virulence factor of S. pyogenes is the surface M protein, which inhibits phagocytosis and shows antigenic variation. Recent data indicate that many M proteins confer phagocytosis resistance because the variable N-terminal region has non-overlapping sites that specifically bind two components of the human immune system, the complement inhibitor C4b-binding protein (C4BP) and IgA-Fc. Concerning puerperal fever, molecular and epidemiological analysis suggests that the S. pyogenes surface protein R28 may have played a pathogenetic role in these epidemics. This article summarizes the properties of M protein and the R28 protein and considers a potential problem encountered in connection with the use of animal models for vaccine development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132186
- author
- Areschoug, Thomas LU ; Carlsson, Fredric LU ; Stålhammar-Carlemalm, Margaretha LU and Lindahl, Gunnar LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C4b-binding protein, Group A streptococcus, Puerperal fever, Vaccines, IgA-Fc
- in
- Vaccine
- volume
- 22 Suppl 1
- issue
- Suppl 1
- pages
- 9 - 14
- publisher
- Elsevier
- external identifiers
-
- wos:000226100200003
- scopus:9644252896
- ISSN
- 1873-2518
- DOI
- 10.1016/j.vaccine.2004.08.010
- language
- English
- LU publication?
- yes
- id
- 001c7563-551b-4b59-b132-1a8fe5d86b9d (old id 132186)
- date added to LUP
- 2016-04-01 11:36:37
- date last changed
- 2022-03-05 03:46:18
@article{001c7563-551b-4b59-b132-1a8fe5d86b9d,
abstract = {{Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively studied virulence factor of S. pyogenes is the surface M protein, which inhibits phagocytosis and shows antigenic variation. Recent data indicate that many M proteins confer phagocytosis resistance because the variable N-terminal region has non-overlapping sites that specifically bind two components of the human immune system, the complement inhibitor C4b-binding protein (C4BP) and IgA-Fc. Concerning puerperal fever, molecular and epidemiological analysis suggests that the S. pyogenes surface protein R28 may have played a pathogenetic role in these epidemics. This article summarizes the properties of M protein and the R28 protein and considers a potential problem encountered in connection with the use of animal models for vaccine development.}},
author = {{Areschoug, Thomas and Carlsson, Fredric and Stålhammar-Carlemalm, Margaretha and Lindahl, Gunnar}},
issn = {{1873-2518}},
keywords = {{C4b-binding protein; Group A streptococcus; Puerperal fever; Vaccines; IgA-Fc}},
language = {{eng}},
number = {{Suppl 1}},
pages = {{9--14}},
publisher = {{Elsevier}},
series = {{Vaccine}},
title = {{Host-pathogen interactions in Streptococcus pyogenes infections, with special reference to puerperal fever and a comment on vaccine development.}},
url = {{https://lup.lub.lu.se/search/files/2559234/624286.pdf}},
doi = {{10.1016/j.vaccine.2004.08.010}},
volume = {{22 Suppl 1}},
year = {{2004}},
}