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Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation

Mahdavi, Jafar; Sondén, Berit; Hurtig, Marina; Olfat, Farzad O.; Forsberg, Lina; Roche, Niamh LU ; Ångström, Jonas; Larsson, Thomas; Teneberg, Susann and Karlsson, Karl-Anders, et al. (2002) In Science 297(5581). p.573-578
Abstract
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.
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type
Contribution to journal
publication status
published
subject
in
Science
volume
297
issue
5581
pages
573 - 578
publisher
The American Association for the Advancement of Science
external identifiers
  • wos:000177054200042
  • pmid:12142529
  • scopus:0037178771
ISSN
1095-9203
DOI
10.1126/science.1069076
language
English
LU publication?
yes
id
25cbbce1-801e-4548-b5a8-810c4cb0d949 (old id 132307)
date added to LUP
2007-07-10 08:21:16
date last changed
2017-12-10 04:27:45
@article{25cbbce1-801e-4548-b5a8-810c4cb0d949,
  abstract     = {Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.},
  author       = {Mahdavi, Jafar and Sondén, Berit and Hurtig, Marina and Olfat, Farzad O. and Forsberg, Lina and Roche, Niamh and Ångström, Jonas and Larsson, Thomas and Teneberg, Susann and Karlsson, Karl-Anders and Altraja, Siiri and Wadström, Torkel and Kersulyte, Dangeruta and Berg, Douglas E. and Dubois, Andre and Petersson, Christoffer and Magnusson, Karl-Eric and Norberg, Thomas and Lindh, Frank and Lundskog, Bertil B. and Arnqvist, Anna and Hammarström, Lennart and Borén, Thomas},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5581},
  pages        = {573--578},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation},
  url          = {http://dx.doi.org/10.1126/science.1069076},
  volume       = {297},
  year         = {2002},
}