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The function of genomes in bioenergetic organelles.

Allen, John LU (2003) In Royal Society of London. Philosophical Transactions B. Biological Sciences 358(1429). p.19-37
Abstract
Mitochondria and chloroplasts are energy-transducing organelles of the cytoplasm of eukaryotic cells. They originated as bacterial symbionts whose host cells acquired respiration from the precursor of the mitochondrion, and oxygenic photosynthesis from the precursor of the chloroplast. The host cells also acquired genetic information from their symbionts, eventually incorporating much of it into their own genomes. Genes of the eukaryotic cell nucleus now encode most mitochondrial and chloroplast proteins. Genes are copied and moved between cellular compartments with relative ease, and there is no obvious obstacle to successful import of any protein precursor from the cytosol. So why are any genes at all retained in cytoplasmic organelles?... (More)
Mitochondria and chloroplasts are energy-transducing organelles of the cytoplasm of eukaryotic cells. They originated as bacterial symbionts whose host cells acquired respiration from the precursor of the mitochondrion, and oxygenic photosynthesis from the precursor of the chloroplast. The host cells also acquired genetic information from their symbionts, eventually incorporating much of it into their own genomes. Genes of the eukaryotic cell nucleus now encode most mitochondrial and chloroplast proteins. Genes are copied and moved between cellular compartments with relative ease, and there is no obvious obstacle to successful import of any protein precursor from the cytosol. So why are any genes at all retained in cytoplasmic organelles? One proposal is that these small but functional genomes provide a location for genes that is close to, and in the same compartment as, their gene products. This co-location facilitates rapid and direct regulatory coupling. Redox control of synthesis de novo is put forward as the common property of those proteins that must be encoded and synthesized within mitochondria and chloroplasts. This testable hypothesis is termed CORR, for co-location for redox regulation. Principles, predictions and consequences of CORR are examined in the context of competing hypotheses and current evidence. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Royal Society of London. Philosophical Transactions B. Biological Sciences
volume
358
issue
1429
pages
19 - 37
publisher
Royal Society
external identifiers
  • pmid:12594916
  • wos:000180920100004
  • scopus:0037471674
ISSN
1471-2970
DOI
10.1098/rstb.2002.1191
language
English
LU publication?
yes
id
e3cc7d70-4f54-43a9-b37b-2e5c124331fa (old id 132653)
date added to LUP
2007-07-04 09:21:41
date last changed
2018-09-30 04:12:40
@article{e3cc7d70-4f54-43a9-b37b-2e5c124331fa,
  abstract     = {Mitochondria and chloroplasts are energy-transducing organelles of the cytoplasm of eukaryotic cells. They originated as bacterial symbionts whose host cells acquired respiration from the precursor of the mitochondrion, and oxygenic photosynthesis from the precursor of the chloroplast. The host cells also acquired genetic information from their symbionts, eventually incorporating much of it into their own genomes. Genes of the eukaryotic cell nucleus now encode most mitochondrial and chloroplast proteins. Genes are copied and moved between cellular compartments with relative ease, and there is no obvious obstacle to successful import of any protein precursor from the cytosol. So why are any genes at all retained in cytoplasmic organelles? One proposal is that these small but functional genomes provide a location for genes that is close to, and in the same compartment as, their gene products. This co-location facilitates rapid and direct regulatory coupling. Redox control of synthesis de novo is put forward as the common property of those proteins that must be encoded and synthesized within mitochondria and chloroplasts. This testable hypothesis is termed CORR, for co-location for redox regulation. Principles, predictions and consequences of CORR are examined in the context of competing hypotheses and current evidence.},
  author       = {Allen, John},
  issn         = {1471-2970},
  language     = {eng},
  number       = {1429},
  pages        = {19--37},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Philosophical Transactions B. Biological Sciences},
  title        = {The function of genomes in bioenergetic organelles.},
  url          = {http://dx.doi.org/10.1098/rstb.2002.1191},
  volume       = {358},
  year         = {2003},
}