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Best clinical management of tenosynovial giant cell tumour (TGCT): A consensus paper from the community of experts

Stacchiotti, Silvia ; Eriksson, Mikael and Bauer, Sebastian (2023) In Cancer Treatment Reviews 112.
Abstract
Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive, mesenchymal tumor arising from the joints, bursa and tendon sheaths. TGCT comprises a nodular- and a diffuse-type, with the former exhibiting mostly indolent course and the latter a locally aggressive behavior. Although usually not life-threatening, TGCT may cause chronic pain and adversely impact function and quality of life (QoL). CSFR1 inhibitors are effective with benefit on symptoms and QoL but are not available in most countries. The degree of uncertainty in selecting the most appropriate therapy and the lack of guidelines on the clinical management of TGCT make the adoption of new treatments inconsistent across the world, with suboptimal outcomes for patients. A... (More)
Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive, mesenchymal tumor arising from the joints, bursa and tendon sheaths. TGCT comprises a nodular- and a diffuse-type, with the former exhibiting mostly indolent course and the latter a locally aggressive behavior. Although usually not life-threatening, TGCT may cause chronic pain and adversely impact function and quality of life (QoL). CSFR1 inhibitors are effective with benefit on symptoms and QoL but are not available in most countries. The degree of uncertainty in selecting the most appropriate therapy and the lack of guidelines on the clinical management of TGCT make the adoption of new treatments inconsistent across the world, with suboptimal outcomes for patients. A global consensus meeting was organized in June 2022, involving experts from several disciplines and patient representatives from SPAGN to define the best evidence-based practice for the optimal approach to TGCT and generate the recommendations presented herein. © 2022 The Author(s) (Less)
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Contribution to journal
publication status
published
subject
keywords
consensus, giant cell tumor of tendon sheath, human, pathology, quality of life, Consensus, Giant Cell Tumor of Tendon Sheath, Humans, Quality of Life
in
Cancer Treatment Reviews
volume
112
article number
102491
publisher
Elsevier
external identifiers
  • scopus:85145424768
  • pmid:36502615
ISSN
0305-7372
DOI
10.1016/j.ctrv.2022.102491
language
English
LU publication?
no
id
1328f38c-a3f8-473d-959d-7001f41c80d7
date added to LUP
2023-01-16 11:28:59
date last changed
2023-01-17 03:00:21
@article{1328f38c-a3f8-473d-959d-7001f41c80d7,
  abstract     = {{Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive, mesenchymal tumor arising from the joints, bursa and tendon sheaths. TGCT comprises a nodular- and a diffuse-type, with the former exhibiting mostly indolent course and the latter a locally aggressive behavior. Although usually not life-threatening, TGCT may cause chronic pain and adversely impact function and quality of life (QoL). CSFR1 inhibitors are effective with benefit on symptoms and QoL but are not available in most countries. The degree of uncertainty in selecting the most appropriate therapy and the lack of guidelines on the clinical management of TGCT make the adoption of new treatments inconsistent across the world, with suboptimal outcomes for patients. A global consensus meeting was organized in June 2022, involving experts from several disciplines and patient representatives from SPAGN to define the best evidence-based practice for the optimal approach to TGCT and generate the recommendations presented herein. © 2022 The Author(s)}},
  author       = {{Stacchiotti, Silvia and Eriksson, Mikael and Bauer, Sebastian}},
  issn         = {{0305-7372}},
  keywords     = {{consensus; giant cell tumor of tendon sheath; human; pathology; quality of life; Consensus; Giant Cell Tumor of Tendon Sheath; Humans; Quality of Life}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Cancer Treatment Reviews}},
  title        = {{Best clinical management of tenosynovial giant cell tumour (TGCT): A consensus paper from the community of experts}},
  url          = {{http://dx.doi.org/10.1016/j.ctrv.2022.102491}},
  doi          = {{10.1016/j.ctrv.2022.102491}},
  volume       = {{112}},
  year         = {{2023}},
}