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Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens.

Lindahl, Gunnar LU ; Stålhammar-Carlemalm, Margaretha LU and Areschoug, Thomas LU (2005) In Clinical Microbiology Reviews 18(1). p.102-102
Abstract
Streptococcus agalactiae (group B Streptococcus) is the major cause of invasive bacterial disease, including meningitis, in the neonatal period. Although prophylactic measures have contributed to a substantial reduction in the number of infections, development of a vaccine remains an important goal. While much work in this field has focused on the S. agalactiae polysaccharide capsule, which is an important virulence factor that elicits protective immunity, surface proteins have received increasing attention as potential virulence factors and vaccine components. Here, we summarize current knowledge about S. agalactiae surface proteins, with emphasis on proteins that have been characterized immunochemically and/or elicit protective immunity... (More)
Streptococcus agalactiae (group B Streptococcus) is the major cause of invasive bacterial disease, including meningitis, in the neonatal period. Although prophylactic measures have contributed to a substantial reduction in the number of infections, development of a vaccine remains an important goal. While much work in this field has focused on the S. agalactiae polysaccharide capsule, which is an important virulence factor that elicits protective immunity, surface proteins have received increasing attention as potential virulence factors and vaccine components. Here, we summarize current knowledge about S. agalactiae surface proteins, with emphasis on proteins that have been characterized immunochemically and/or elicit protective immunity in animal models. These surface proteins have been implicated in interactions with human epithelial cells, binding to extracellular matrix components, and/or evasion of host immunity. Of note, several S. agalactiae surface proteins are related to surface proteins identified in other bacterial pathogens, emphasizing the general interest of the S. agalactiae proteins. Because some S. agalactiae surface proteins elicit protective immunity, they hold promise as components in a vaccine based only on proteins or as carriers in polysaccharide conjugate vaccines. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Microbiology Reviews
volume
18
issue
1
pages
102 - 102
publisher
American Society for Microbiology
external identifiers
  • wos:000226575300006
  • pmid:15653821
  • scopus:12844278673
ISSN
0893-8512
DOI
10.1128/CMR.18.1.102-127.2005
language
English
LU publication?
yes
id
8d234f65-ed22-4f3c-b9cb-1b7e319cc116 (old id 133098)
date added to LUP
2007-07-10 07:45:34
date last changed
2017-10-22 04:50:16
@article{8d234f65-ed22-4f3c-b9cb-1b7e319cc116,
  abstract     = {Streptococcus agalactiae (group B Streptococcus) is the major cause of invasive bacterial disease, including meningitis, in the neonatal period. Although prophylactic measures have contributed to a substantial reduction in the number of infections, development of a vaccine remains an important goal. While much work in this field has focused on the S. agalactiae polysaccharide capsule, which is an important virulence factor that elicits protective immunity, surface proteins have received increasing attention as potential virulence factors and vaccine components. Here, we summarize current knowledge about S. agalactiae surface proteins, with emphasis on proteins that have been characterized immunochemically and/or elicit protective immunity in animal models. These surface proteins have been implicated in interactions with human epithelial cells, binding to extracellular matrix components, and/or evasion of host immunity. Of note, several S. agalactiae surface proteins are related to surface proteins identified in other bacterial pathogens, emphasizing the general interest of the S. agalactiae proteins. Because some S. agalactiae surface proteins elicit protective immunity, they hold promise as components in a vaccine based only on proteins or as carriers in polysaccharide conjugate vaccines.},
  author       = {Lindahl, Gunnar and Stålhammar-Carlemalm, Margaretha and Areschoug, Thomas},
  issn         = {0893-8512},
  language     = {eng},
  number       = {1},
  pages        = {102--102},
  publisher    = {American Society for Microbiology},
  series       = {Clinical Microbiology Reviews},
  title        = {Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens.},
  url          = {http://dx.doi.org/10.1128/CMR.18.1.102-127.2005},
  volume       = {18},
  year         = {2005},
}