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Effects of the Androgen Antagonist Flutamide and the Serotonin Reuptake Inhibitor Citalopram in Bulimia Nervosa: A Placebo-Controlled Pilot Study.

Sundblad, Charlotta; Landén, Mikael; Eriksson, Tomas LU ; Bergman, Lars and Eriksson, Elias (2005) In Journal of Clinical Psychopharmacology 25(1). p.85-88
Abstract
colon; Prompted by previous studies suggesting that bulimia nervosa in women may be associated with elevated serum levels of testosterone, we have evaluated the possible effect of androgen antagonism in this condition. To this end, women meeting the DSM-IV criteria of bulimia nervosa, purging type, were treated in a one-center study with the androgen receptor antagonist flutamide (n = 9), the serotonin reuptake inhibitor citalopram (n = 15), flutamide plus citalopram (n = 10), or placebo (n = 12) for 3 months using a double-blind design. Self-rated global assessment of symptom intensity suggests all active treatments to be superior to placebo. The reduction in binge eating compared with baseline was statistically significant in both groups... (More)
colon; Prompted by previous studies suggesting that bulimia nervosa in women may be associated with elevated serum levels of testosterone, we have evaluated the possible effect of androgen antagonism in this condition. To this end, women meeting the DSM-IV criteria of bulimia nervosa, purging type, were treated in a one-center study with the androgen receptor antagonist flutamide (n = 9), the serotonin reuptake inhibitor citalopram (n = 15), flutamide plus citalopram (n = 10), or placebo (n = 12) for 3 months using a double-blind design. Self-rated global assessment of symptom intensity suggests all active treatments to be superior to placebo. The reduction in binge eating compared with baseline was statistically significant in both groups given flutamide but not in the groups given citalopram only or placebo. A moderate and reversible increase in serum transaminase levels led to discontinuation in two subjects in the flutamide group. It is concluded that blockade of androgen receptors may reduce some of the symptoms of bulimia nervosa in women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Psychopharmacology
volume
25
issue
1
pages
85 - 88
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000226451200013
  • pmid:15643104
  • scopus:12344287791
ISSN
0271-0749
DOI
10.1097/01.jcp.0000150222.31007.a9
language
English
LU publication?
yes
id
af08a914-4abc-48e6-aaa0-5ca29859414f (old id 133225)
alternative location
http://www.psychopharmacology.com/pt/re/jclnpsychopharm/abstract.00004714-200502000-00013.htm
date added to LUP
2007-07-30 14:45:03
date last changed
2017-04-16 04:06:52
@article{af08a914-4abc-48e6-aaa0-5ca29859414f,
  abstract     = {colon; Prompted by previous studies suggesting that bulimia nervosa in women may be associated with elevated serum levels of testosterone, we have evaluated the possible effect of androgen antagonism in this condition. To this end, women meeting the DSM-IV criteria of bulimia nervosa, purging type, were treated in a one-center study with the androgen receptor antagonist flutamide (n = 9), the serotonin reuptake inhibitor citalopram (n = 15), flutamide plus citalopram (n = 10), or placebo (n = 12) for 3 months using a double-blind design. Self-rated global assessment of symptom intensity suggests all active treatments to be superior to placebo. The reduction in binge eating compared with baseline was statistically significant in both groups given flutamide but not in the groups given citalopram only or placebo. A moderate and reversible increase in serum transaminase levels led to discontinuation in two subjects in the flutamide group. It is concluded that blockade of androgen receptors may reduce some of the symptoms of bulimia nervosa in women.},
  author       = {Sundblad, Charlotta and Landén, Mikael and Eriksson, Tomas and Bergman, Lars and Eriksson, Elias},
  issn         = {0271-0749},
  language     = {eng},
  number       = {1},
  pages        = {85--88},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Clinical Psychopharmacology},
  title        = {Effects of the Androgen Antagonist Flutamide and the Serotonin Reuptake Inhibitor Citalopram in Bulimia Nervosa: A Placebo-Controlled Pilot Study.},
  url          = {http://dx.doi.org/10.1097/01.jcp.0000150222.31007.a9},
  volume       = {25},
  year         = {2005},
}