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Hypothyroidism Is Common in Turner Syndrome: Results of a Five-Year Follow-Up

El Masnaouy, Mostafa; Bryman, Inger; Berntorp, Kerstin LU ; Hanson, Charles; Wilhelmsen, Lars and Landin-Wilhelmsen, Kerstin (2005) In Journal of Clinical Endocrinology and Metabolism 90(4). p.2131-2135
Abstract
Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without... (More)
Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without hypothyroidism (P < 0.05), evenly distributed between the karyotype 45, X and mosaicism. A high body mass index, but not a family history or blood lipids, was associated with hypothyroidism in TS. After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase. Altogether, 34 (37%) TS women had hypothyroidism after the 5-yr follow-up. Autoimmune hypothyroidism was common, with an annual incidence of 3.2% in TS. Thyroid function should be checked regularly in TS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
90
issue
4
pages
2131 - 2135
publisher
The Endocrine Society
external identifiers
  • pmid:15623818
  • wos:000228198900034
  • scopus:19044377827
ISSN
1945-7197
DOI
10.1210/jc.2004-1262
language
English
LU publication?
yes
id
7463a984-86fa-4ea1-9db7-a674dddb3029 (old id 133384)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15623818&dopt=Abstract
date added to LUP
2007-07-18 11:46:06
date last changed
2017-11-12 03:53:39
@article{7463a984-86fa-4ea1-9db7-a674dddb3029,
  abstract     = {Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P &lt; 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P &lt; 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without hypothyroidism (P &lt; 0.05), evenly distributed between the karyotype 45, X and mosaicism. A high body mass index, but not a family history or blood lipids, was associated with hypothyroidism in TS. After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase. Altogether, 34 (37%) TS women had hypothyroidism after the 5-yr follow-up. Autoimmune hypothyroidism was common, with an annual incidence of 3.2% in TS. Thyroid function should be checked regularly in TS.},
  author       = {El Masnaouy, Mostafa and Bryman, Inger and Berntorp, Kerstin and Hanson, Charles and Wilhelmsen, Lars and Landin-Wilhelmsen, Kerstin},
  issn         = {1945-7197},
  language     = {eng},
  number       = {4},
  pages        = {2131--2135},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Hypothyroidism Is Common in Turner Syndrome: Results of a Five-Year Follow-Up},
  url          = {http://dx.doi.org/10.1210/jc.2004-1262},
  volume       = {90},
  year         = {2005},
}