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Heterogeneity of cardiovascular risk among smokers is related to degree of carbon monoxide exposure.

Hedblad, Bo LU ; Ögren, Mats; Engström, Gunnar LU ; Wollmer, Per LU and Janzon, Lars LU (2005) In Atherosclerosis 179(1). p.177-183
Abstract
Background:



Between smokers matched for daily tobacco consumption there are marked variations of the cardiovascular risk. This follow up of the population based cohort “Men born in 1914” from Malmö, Sweden, explored whether this is accounted for by the levels of carbon monoxide (CO).



Methods:



Three hundred and sixty-five men without history of cardiovascular disease (CVD) were followed over 27 years. Leg artery disease was defined as a systolic ankle–arm pressure ratio (ABPI) below 0.9 in either leg. Incidence of myocardial infarction (MI), stroke and deaths is based on linkage with regional and national registers. The distribution of CO in blood and expired air, respectively, was... (More)
Background:



Between smokers matched for daily tobacco consumption there are marked variations of the cardiovascular risk. This follow up of the population based cohort “Men born in 1914” from Malmö, Sweden, explored whether this is accounted for by the levels of carbon monoxide (CO).



Methods:



Three hundred and sixty-five men without history of cardiovascular disease (CVD) were followed over 27 years. Leg artery disease was defined as a systolic ankle–arm pressure ratio (ABPI) below 0.9 in either leg. Incidence of myocardial infarction (MI), stroke and deaths is based on linkage with regional and national registers. The distribution of CO in blood and expired air, respectively, was divided into quartiles.



Results:



There was a significant inverse relation between ABPI and CO in blood and expired air. Incidence of CVD events and deaths increased progressively with degree of CO exposure. Men with CO in the top quartile had significantly increased risks of CVD events (RR: 2.2; 95% CI: 1.00–4.6) and cardiovascular deaths (RR: 3.2, CI: 1.2–8.3), adjusted for daily tobacco consumption and other potential confounders.



Conclusions:



In smokers, the prevalence of leg atherosclerosis and incidence of cardiovascular disease is related to the amount of carbon monoxide in blood or expired air. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epidemiology, Atherosclerosis, Carbon monoxide, CV disease
in
Atherosclerosis
volume
179
issue
1
pages
177 - 183
publisher
Elsevier
external identifiers
  • wos:000227571700022
  • pmid:15721025
  • scopus:13844256197
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2004.10.005
language
English
LU publication?
yes
id
c6422d21-2cbf-4ae4-b901-e6fb1ac3e985 (old id 133656)
date added to LUP
2007-07-25 09:30:27
date last changed
2017-01-01 04:30:20
@article{c6422d21-2cbf-4ae4-b901-e6fb1ac3e985,
  abstract     = {Background:<br/><br>
<br/><br>
Between smokers matched for daily tobacco consumption there are marked variations of the cardiovascular risk. This follow up of the population based cohort “Men born in 1914” from Malmö, Sweden, explored whether this is accounted for by the levels of carbon monoxide (CO).<br/><br>
<br/><br>
Methods:<br/><br>
<br/><br>
Three hundred and sixty-five men without history of cardiovascular disease (CVD) were followed over 27 years. Leg artery disease was defined as a systolic ankle–arm pressure ratio (ABPI) below 0.9 in either leg. Incidence of myocardial infarction (MI), stroke and deaths is based on linkage with regional and national registers. The distribution of CO in blood and expired air, respectively, was divided into quartiles.<br/><br>
<br/><br>
Results:<br/><br>
<br/><br>
There was a significant inverse relation between ABPI and CO in blood and expired air. Incidence of CVD events and deaths increased progressively with degree of CO exposure. Men with CO in the top quartile had significantly increased risks of CVD events (RR: 2.2; 95% CI: 1.00–4.6) and cardiovascular deaths (RR: 3.2, CI: 1.2–8.3), adjusted for daily tobacco consumption and other potential confounders.<br/><br>
<br/><br>
Conclusions:<br/><br>
<br/><br>
In smokers, the prevalence of leg atherosclerosis and incidence of cardiovascular disease is related to the amount of carbon monoxide in blood or expired air.},
  author       = {Hedblad, Bo and Ögren, Mats and Engström, Gunnar and Wollmer, Per and Janzon, Lars},
  issn         = {1879-1484},
  keyword      = {Epidemiology,Atherosclerosis,Carbon monoxide,CV disease},
  language     = {eng},
  number       = {1},
  pages        = {177--183},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Heterogeneity of cardiovascular risk among smokers is related to degree of carbon monoxide exposure.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2004.10.005},
  volume       = {179},
  year         = {2005},
}