Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
Melander, Olle LU
; Frandsen, E
; Magnusson, Martin
LU
; Grubb, Anders
LU
; Jovinge, Stefan
LU
and Groop, Leif
LU
(2005)
In Journal of Internal Medicine
257(3).
p.281-288
- Abstract
- Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.
Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1)... (More) - Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.
Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1) and 1 week on a low-salt diet (10 mmol day-1). Nt-proANP was measured in 253 patients with type 2 diabetes and in 230 nondiabetic subjects aged 40–70 years, all without a history of coronary heart disease.
Results. Amongst the 30 subjects, in whom salt sensitivity was directly measured, Nt-proBNP was not correlated with salt sensitivity (R = −0.18, P = 0.35). Nt-proANP (median, interquartile range) was lower in patients with type 2 diabetes (505, 387–661 pmol L-1) than in nondiabetic subjects (536, 421–696 pmol L-1) (P = 0.02). In a multiple regression analysis heart rate (P < 0.00001), diastolic blood pressure (P = 0.02) and diabetes status (P = 0.02) were inversely related whereas age (P < 0.00001), cystatin C (P = 0.0006), hypertension treatment (P = 0.002) and female sex (P = 0.006) were directly related to ln(Nt-proANP).
Conclusion. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/133727
- author
- Melander, Olle
LU
; Frandsen, E
; Magnusson, Martin
LU
; Grubb, Anders
LU
; Jovinge, Stefan
LU
and Groop, Leif
LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Internal Medicine
- volume
- 257
- issue
- 3
- pages
- 281 - 288
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000227556500008
- pmid:15715685
- scopus:14844292116
- pmid:15715685
- ISSN
- 1365-2796
- DOI
- 10.1111/j.1365-2796.2005.01449.x
- language
- English
- LU publication?
- yes
- id
- 66b56efa-5186-4331-9c67-14633137a9c8 (old id 133727)
- date added to LUP
- 2016-04-01 16:41:46
- date last changed
- 2024-03-13 10:56:28
@article{66b56efa-5186-4331-9c67-14633137a9c8,
abstract = {{Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.<br/><br>
<br/><br>
Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1) and 1 week on a low-salt diet (10 mmol day-1). Nt-proANP was measured in 253 patients with type 2 diabetes and in 230 nondiabetic subjects aged 40–70 years, all without a history of coronary heart disease.<br/><br>
<br/><br>
Results. Amongst the 30 subjects, in whom salt sensitivity was directly measured, Nt-proBNP was not correlated with salt sensitivity (R = −0.18, P = 0.35). Nt-proANP (median, interquartile range) was lower in patients with type 2 diabetes (505, 387–661 pmol L-1) than in nondiabetic subjects (536, 421–696 pmol L-1) (P = 0.02). In a multiple regression analysis heart rate (P < 0.00001), diastolic blood pressure (P = 0.02) and diabetes status (P = 0.02) were inversely related whereas age (P < 0.00001), cystatin C (P = 0.0006), hypertension treatment (P = 0.002) and female sex (P = 0.006) were directly related to ln(Nt-proANP).<br/><br>
<br/><br>
Conclusion. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes.}},
author = {{Melander, Olle and Frandsen, E and Magnusson, Martin and Grubb, Anders and Jovinge, Stefan and Groop, Leif}},
issn = {{1365-2796}},
language = {{eng}},
number = {{3}},
pages = {{281--288}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.}},
url = {{https://lup.lub.lu.se/search/files/4753088/624389.pdf}},
doi = {{10.1111/j.1365-2796.2005.01449.x}},
volume = {{257}},
year = {{2005}},
}