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Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.

Melander, Olle LU ; Frandsen, E; Magnusson, Martin LU ; Grubb, Anders LU ; Jovinge, Stefan LU and Groop, Leif LU (2005) In Journal of Internal Medicine 257(3). p.281-288
Abstract
Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.



Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1)... (More)
Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.



Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1) and 1 week on a low-salt diet (10 mmol day-1). Nt-proANP was measured in 253 patients with type 2 diabetes and in 230 nondiabetic subjects aged 40–70 years, all without a history of coronary heart disease.



Results. Amongst the 30 subjects, in whom salt sensitivity was directly measured, Nt-proBNP was not correlated with salt sensitivity (R = −0.18, P = 0.35). Nt-proANP (median, interquartile range) was lower in patients with type 2 diabetes (505, 387–661 pmol L-1) than in nondiabetic subjects (536, 421–696 pmol L-1) (P = 0.02). In a multiple regression analysis heart rate (P < 0.00001), diastolic blood pressure (P = 0.02) and diabetes status (P = 0.02) were inversely related whereas age (P < 0.00001), cystatin C (P = 0.0006), hypertension treatment (P = 0.002) and female sex (P = 0.006) were directly related to ln(Nt-proANP).



Conclusion. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
257
issue
3
pages
281 - 288
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000227556500008
  • pmid:15715685
  • scopus:14844292116
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2005.01449.x
language
English
LU publication?
yes
id
66b56efa-5186-4331-9c67-14633137a9c8 (old id 133727)
date added to LUP
2007-07-24 09:14:09
date last changed
2017-05-16 13:18:12
@article{66b56efa-5186-4331-9c67-14633137a9c8,
  abstract     = {Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.<br/><br>
<br/><br>
Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1) and 1 week on a low-salt diet (10 mmol day-1). Nt-proANP was measured in 253 patients with type 2 diabetes and in 230 nondiabetic subjects aged 40–70 years, all without a history of coronary heart disease.<br/><br>
<br/><br>
Results. Amongst the 30 subjects, in whom salt sensitivity was directly measured, Nt-proBNP was not correlated with salt sensitivity (R = −0.18, P = 0.35). Nt-proANP (median, interquartile range) was lower in patients with type 2 diabetes (505, 387–661 pmol L-1) than in nondiabetic subjects (536, 421–696 pmol L-1) (P = 0.02). In a multiple regression analysis heart rate (P &lt; 0.00001), diastolic blood pressure (P = 0.02) and diabetes status (P = 0.02) were inversely related whereas age (P &lt; 0.00001), cystatin C (P = 0.0006), hypertension treatment (P = 0.002) and female sex (P = 0.006) were directly related to ln(Nt-proANP).<br/><br>
<br/><br>
Conclusion. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes.},
  author       = {Melander, Olle and Frandsen, E and Magnusson, Martin and Grubb, Anders and Jovinge, Stefan and Groop, Leif},
  issn         = {1365-2796},
  language     = {eng},
  number       = {3},
  pages        = {281--288},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2005.01449.x},
  volume       = {257},
  year         = {2005},
}