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Time course of postnatal motor development in ferrets: ontogenetic and comparative perspectives.

Christensson, Maria LU and Garwicz, Martin LU (2005) In Behavioural Brain Research 158(2). p.231-242
Abstract
We assess relative time courses of motor development in ferrets and rats and evaluate ferrets as experimental animals for studies of motor development. Motor behaviour of ferret pups was characterized in daily sessions from postnatal day (P) 2 to P63. Observations concerning rotational locomotion ('pivoting'), crawling, walking, upright standing ('rearing') and walking on a narrow path; righting on a surface, in mid-air and on an inclined plane ('geotaxis') were quantified in detail and compared with published data on rat motor development. Besides providing a comprehensive characterization of ferret motor development, our results demonstrate that relative time courses of emergence of motor skills in ferrets and rats are highly similar... (More)
We assess relative time courses of motor development in ferrets and rats and evaluate ferrets as experimental animals for studies of motor development. Motor behaviour of ferret pups was characterized in daily sessions from postnatal day (P) 2 to P63. Observations concerning rotational locomotion ('pivoting'), crawling, walking, upright standing ('rearing') and walking on a narrow path; righting on a surface, in mid-air and on an inclined plane ('geotaxis') were quantified in detail and compared with published data on rat motor development. Besides providing a comprehensive characterization of ferret motor development, our results demonstrate that relative time courses of emergence of motor skills in ferrets and rats are highly similar despite substantially different duration of postnatal periods. The relationship between species was determined by linear regression analysis of an x-y-plot of postnatal ages (y: ferret days; x: rat days) corresponding to given levels of performance of specific skills. The model equation y = 2.46x-4.18 represents the conversion between time courses of rat and ferret motor development. Remarkably, the model explained 81% of data variance (r2 = 0.81) and should hence be useful for translation of motor developmental data between ferret and rat and for comparisons between motor and other functions in ferrets. The highly conserved relative time course also has more general implications for the understanding of comparative aspects of development. In addition, the high reproducibility of data within the present study underscores the suitability of the ferret as an experimental animal for studies of motor development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Locomotion, Motor behaviour, Open field, Geotaxis, Righting, Ferret–rat comparison
in
Behavioural Brain Research
volume
158
issue
2
pages
231 - 242
publisher
Elsevier
external identifiers
  • wos:000227300700005
  • pmid:15698889
  • scopus:13444279968
ISSN
0166-4328
DOI
10.1016/j.bbr.2004.09.003
language
English
LU publication?
yes
id
da55fefd-f675-49e9-b204-3a30864a3b5b (old id 133863)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15698889&dopt=Abstract
date added to LUP
2007-07-11 11:50:05
date last changed
2017-01-01 04:27:38
@article{da55fefd-f675-49e9-b204-3a30864a3b5b,
  abstract     = {We assess relative time courses of motor development in ferrets and rats and evaluate ferrets as experimental animals for studies of motor development. Motor behaviour of ferret pups was characterized in daily sessions from postnatal day (P) 2 to P63. Observations concerning rotational locomotion ('pivoting'), crawling, walking, upright standing ('rearing') and walking on a narrow path; righting on a surface, in mid-air and on an inclined plane ('geotaxis') were quantified in detail and compared with published data on rat motor development. Besides providing a comprehensive characterization of ferret motor development, our results demonstrate that relative time courses of emergence of motor skills in ferrets and rats are highly similar despite substantially different duration of postnatal periods. The relationship between species was determined by linear regression analysis of an x-y-plot of postnatal ages (y: ferret days; x: rat days) corresponding to given levels of performance of specific skills. The model equation y = 2.46x-4.18 represents the conversion between time courses of rat and ferret motor development. Remarkably, the model explained 81% of data variance (r2 = 0.81) and should hence be useful for translation of motor developmental data between ferret and rat and for comparisons between motor and other functions in ferrets. The highly conserved relative time course also has more general implications for the understanding of comparative aspects of development. In addition, the high reproducibility of data within the present study underscores the suitability of the ferret as an experimental animal for studies of motor development.},
  author       = {Christensson, Maria and Garwicz, Martin},
  issn         = {0166-4328},
  keyword      = {Locomotion,Motor behaviour,Open field,Geotaxis,Righting,Ferret–rat comparison},
  language     = {eng},
  number       = {2},
  pages        = {231--242},
  publisher    = {Elsevier},
  series       = {Behavioural Brain Research},
  title        = {Time course of postnatal motor development in ferrets: ontogenetic and comparative perspectives.},
  url          = {http://dx.doi.org/10.1016/j.bbr.2004.09.003},
  volume       = {158},
  year         = {2005},
}