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Complement c3 is a risk factor for the development of diabetes: a population-based cohort study.

Engström, Gunnar LU ; Hedblad, Bo LU ; Eriksson, Karl-Fredrik LU ; Janzon, Lars LU and Lindgärde, Folke LU (2005) In Diabetes 54(2). p.570-575
Abstract
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, α1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38–50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1–5.3), 2.9... (More)
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, α1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38–50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1–5.3), 2.9 (1.4–6.0), and 5.6 (2.8–10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
54
issue
2
pages
570 - 575
publisher
American Diabetes Association Inc.
external identifiers
  • wos:000226613400033
  • pmid:15677517
  • scopus:12744279313
ISSN
1939-327X
DOI
10.2337/diabetes.54.2.570
language
English
LU publication?
yes
id
23b108d7-6f68-4505-a603-3cda48918afe (old id 134012)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15677517&dopt=Abstract
date added to LUP
2007-07-18 14:41:35
date last changed
2017-10-22 04:40:30
@article{23b108d7-6f68-4505-a603-3cda48918afe,
  abstract     = {Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, α1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38–50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1–5.3), 2.9 (1.4–6.0), and 5.6 (2.8–10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P &lt; 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.},
  author       = {Engström, Gunnar and Hedblad, Bo and Eriksson, Karl-Fredrik and Janzon, Lars and Lindgärde, Folke},
  issn         = {1939-327X},
  language     = {eng},
  number       = {2},
  pages        = {570--575},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Complement c3 is a risk factor for the development of diabetes: a population-based cohort study.},
  url          = {http://dx.doi.org/10.2337/diabetes.54.2.570},
  volume       = {54},
  year         = {2005},
}