CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays
(2003) In Blood 101(6). p.2307-2313- Abstract
- A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed using a novel statistical analysis scheme created to retrieve the most likely expression... (More)
- A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed using a novel statistical analysis scheme created to retrieve the most likely expression pattern of CD44 ligation. Our results show that genes such as interleukin-6 (IL-6), IL-1alpha , and beta 2-adrenergic receptor (beta 2-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/134293
- author
- Högerkorp, Carl-Magnus LU ; Bilke, Sven LU ; Breslin, Thomas LU ; Ingvarsson, Sigurdur LU and Borrebaeck, Carl LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 101
- issue
- 6
- pages
- 2307 - 2313
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000181432600036
- pmid:12411303
- scopus:0037443514
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2002-06-1837
- language
- English
- LU publication?
- yes
- id
- 954a5148-bb44-44ce-b398-7fc65f645b4a (old id 134293)
- date added to LUP
- 2016-04-01 12:22:36
- date last changed
- 2024-01-08 18:22:44
@article{954a5148-bb44-44ce-b398-7fc65f645b4a, abstract = {{A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed using a novel statistical analysis scheme created to retrieve the most likely expression pattern of CD44 ligation. Our results show that genes such as interleukin-6 (IL-6), IL-1alpha , and beta 2-adrenergic receptor (beta 2-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation.}}, author = {{Högerkorp, Carl-Magnus and Bilke, Sven and Breslin, Thomas and Ingvarsson, Sigurdur and Borrebaeck, Carl}}, issn = {{1528-0020}}, language = {{eng}}, number = {{6}}, pages = {{2307--2313}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays}}, url = {{http://dx.doi.org/10.1182/blood-2002-06-1837}}, doi = {{10.1182/blood-2002-06-1837}}, volume = {{101}}, year = {{2003}}, }