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The human antibody repertoire to infectious agents: implications for disease pathogenesis

Ohlin, Mats LU and Zouali, Moncef (2003) In Molecular Immunology 40(1). p.1-11
Abstract
Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A more thorough understanding of the interplay between these factors will eventually allow us to elucidate the underlying mechanisms of disease susceptibility following infection, and to design potent vaccines and other immunomodulating reagents.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Immunology
volume
40
issue
1
pages
1 - 11
publisher
Pergamon
external identifiers
  • pmid:12909126
  • wos:000184975700001
  • scopus:0042697222
ISSN
1872-9142
DOI
language
English
LU publication?
yes
id
500a98df-c429-4941-8593-f43752cc5751 (old id 134316)
date added to LUP
2007-07-09 13:30:57
date last changed
2018-05-29 10:35:49
@article{500a98df-c429-4941-8593-f43752cc5751,
  abstract     = {Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A more thorough understanding of the interplay between these factors will eventually allow us to elucidate the underlying mechanisms of disease susceptibility following infection, and to design potent vaccines and other immunomodulating reagents.},
  author       = {Ohlin, Mats and Zouali, Moncef},
  issn         = {1872-9142},
  language     = {eng},
  number       = {1},
  pages        = {1--11},
  publisher    = {Pergamon},
  series       = {Molecular Immunology},
  title        = {The human antibody repertoire to infectious agents: implications for disease pathogenesis},
  url          = {http://dx.doi.org/},
  volume       = {40},
  year         = {2003},
}