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Increased stiffness of the abdominal aorta in women with rheumatoid arthritis.

Turesson, Carl LU ; Jacobsson, Lennart LU ; Rydén Ahlgren, Åsa LU ; Sturfelt, Gunnar LU ; Wollmer, Per LU and Länne, T (2005) In Rheumatology 44(7). p.896-901
Abstract
Objective. To study the distensibility and the diameter of the abdominal aorta and the common carotid artery (CCA) in patients with rheumatoid arthritis (RA), and investigate the relation between mechanical properties of these arteries and disease severity.



Methods. One hundred and one patients with RA (33 consecutive cases with extra-articular manifestations, and 68 subjects with non-extra-articular disease, matched for age, sex and disease duration) were investigated. Echo-tracking ultrasonography was used to measure stiffness and mean diameter of the abdominal aorta and the CCA. The patients were compared with healthy individuals from the corresponding age group (n=74 for measurements of the aorta, n=64 for the CCA).... (More)
Objective. To study the distensibility and the diameter of the abdominal aorta and the common carotid artery (CCA) in patients with rheumatoid arthritis (RA), and investigate the relation between mechanical properties of these arteries and disease severity.



Methods. One hundred and one patients with RA (33 consecutive cases with extra-articular manifestations, and 68 subjects with non-extra-articular disease, matched for age, sex and disease duration) were investigated. Echo-tracking ultrasonography was used to measure stiffness and mean diameter of the abdominal aorta and the CCA. The patients were compared with healthy individuals from the corresponding age group (n=74 for measurements of the aorta, n=64 for the CCA). Predicted values for stiffness and mean diameter, based on age and sex, were calculated.



Results. Stiffness of the abdominal aorta was increased in women with RA [mean percentage of predicted value (% predicted) 180; 95% confidence interval (95% CI) 150–211] but not in men (% predicted 99; 95% CI 75–122). CCA stiffness was less markedly increased, and mean diameters of the aorta and the CCA were not different from the expected. In the RA cohort, patients with extra-articular manifestations tended to have greater stiffness of the aorta (P=0.11), and disability, as indicated by a higher Health Assessment Questionnaire score, was associated with increased aortic stiffness (P=0.04).



Conclusion. RA is associated with decreased distensibility of the abdominal aorta in females, and such changes seem to correlate with disease severity. We suggest that arterial stiffness is an important factor in cardiovascular co-morbidity in RA. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease, Aorta, Ultrasound, Rheumatoid arthritis, Arterial distensibility, Extra-articular manifestations, Disease severity
in
Rheumatology
volume
44
issue
7
pages
896 - 901
publisher
Oxford University Press
external identifiers
  • pmid:15784628
  • wos:000230205000012
  • scopus:22844449569
ISSN
1462-0332
DOI
10.1093/rheumatology/keh607
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Rheumatology Research Unit (013243310), Department of Rheumatology (013036000), Clinical Physiology (013242300), Emergency medicine/Medicine/Surgery (013240200), Clinical Physiology and Nuclear Medicine Unit (013242320)
id
8b4eb202-aa48-47ea-a1b8-7a342aa54fdd (old id 134814)
date added to LUP
2016-04-01 16:59:26
date last changed
2020-06-03 02:52:32
@article{8b4eb202-aa48-47ea-a1b8-7a342aa54fdd,
  abstract     = {Objective. To study the distensibility and the diameter of the abdominal aorta and the common carotid artery (CCA) in patients with rheumatoid arthritis (RA), and investigate the relation between mechanical properties of these arteries and disease severity.<br/><br>
<br/><br>
Methods. One hundred and one patients with RA (33 consecutive cases with extra-articular manifestations, and 68 subjects with non-extra-articular disease, matched for age, sex and disease duration) were investigated. Echo-tracking ultrasonography was used to measure stiffness and mean diameter of the abdominal aorta and the CCA. The patients were compared with healthy individuals from the corresponding age group (n=74 for measurements of the aorta, n=64 for the CCA). Predicted values for stiffness and mean diameter, based on age and sex, were calculated.<br/><br>
<br/><br>
Results. Stiffness of the abdominal aorta was increased in women with RA [mean percentage of predicted value (% predicted) 180; 95% confidence interval (95% CI) 150–211] but not in men (% predicted 99; 95% CI 75–122). CCA stiffness was less markedly increased, and mean diameters of the aorta and the CCA were not different from the expected. In the RA cohort, patients with extra-articular manifestations tended to have greater stiffness of the aorta (P=0.11), and disability, as indicated by a higher Health Assessment Questionnaire score, was associated with increased aortic stiffness (P=0.04).<br/><br>
<br/><br>
Conclusion. RA is associated with decreased distensibility of the abdominal aorta in females, and such changes seem to correlate with disease severity. We suggest that arterial stiffness is an important factor in cardiovascular co-morbidity in RA.},
  author       = {Turesson, Carl and Jacobsson, Lennart and Rydén Ahlgren, Åsa and Sturfelt, Gunnar and Wollmer, Per and Länne, T},
  issn         = {1462-0332},
  language     = {eng},
  number       = {7},
  pages        = {896--901},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Increased stiffness of the abdominal aorta in women with rheumatoid arthritis.},
  url          = {http://dx.doi.org/10.1093/rheumatology/keh607},
  doi          = {10.1093/rheumatology/keh607},
  volume       = {44},
  year         = {2005},
}