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ATP Depletion and Cell Death in the Neonatal Lamb Ductus Arteriosus.

Levin, Max; Goldbarg, Seth; Lindqvist, Anders LU ; Swärd, Karl LU ; Roman, Christine; Liu, Bao Mei; Hultén, Lillemor Mattsson; Borén, Jan and Clyman, Ronald I (2005) In Pediatric Research 57(6). p.801-805
Abstract
Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose... (More)
Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose utilization. However, the immature ductus is just as susceptible as the mature ductus to ATP depletion when glucose supplies are restricted. The extensive degree of cell death that occurs in the newborn ductus after birth is associated primarily with ATP depletion. The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
57
issue
6
pages
801 - 805
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000229293600010
  • pmid:15774827
  • scopus:19444379749
ISSN
1530-0447
DOI
10.1203/01.PDR.0000157791.95954.56
language
English
LU publication?
yes
id
44bf0c9b-a5af-4c4c-94c0-46363f4e5c34 (old id 134893)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15774827&dopt=Abstract
date added to LUP
2007-07-16 14:46:25
date last changed
2017-01-01 05:05:56
@article{44bf0c9b-a5af-4c4c-94c0-46363f4e5c34,
  abstract     = {Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose utilization. However, the immature ductus is just as susceptible as the mature ductus to ATP depletion when glucose supplies are restricted. The extensive degree of cell death that occurs in the newborn ductus after birth is associated primarily with ATP depletion. The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure.},
  author       = {Levin, Max and Goldbarg, Seth and Lindqvist, Anders and Swärd, Karl and Roman, Christine and Liu, Bao Mei and Hultén, Lillemor Mattsson and Borén, Jan and Clyman, Ronald I},
  issn         = {1530-0447},
  language     = {eng},
  number       = {6},
  pages        = {801--805},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {ATP Depletion and Cell Death in the Neonatal Lamb Ductus Arteriosus.},
  url          = {http://dx.doi.org/10.1203/01.PDR.0000157791.95954.56},
  volume       = {57},
  year         = {2005},
}