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Diurnal IOP fluctuation: not an independent risk factor for glaucomatous visual field loss in high-risk ocular hypertension.

Bengtsson, Boel LU and Heijl, Anders LU (2005) In Graefe's Archive for Clinical and Experimental Ophthalmology 243(Mar 9). p.513-518
Abstract
Purpose: To establish whether intraocular pressure (IOP) fluctuations contribute to the risk of developing glaucoma in patients with high-risk ocular hypertension. Methods: Ninety patients included in the Malmo Ocular Hypertension Study were examined every 3 months with office-hours diurnal tension curves and computerised perimetry. Patients were followed up prospectively for 10 years or until glaucomatous visual field loss could be demonstrated. Poststudy data were included in the analyses, extending maximum follow-up to 17 years. Results: After 17 years, 37 patients had developed glaucomatous visual field defects. When applying univariate Cox regression analyses, mean IOP of all measurements during the prospective part of the study was a... (More)
Purpose: To establish whether intraocular pressure (IOP) fluctuations contribute to the risk of developing glaucoma in patients with high-risk ocular hypertension. Methods: Ninety patients included in the Malmo Ocular Hypertension Study were examined every 3 months with office-hours diurnal tension curves and computerised perimetry. Patients were followed up prospectively for 10 years or until glaucomatous visual field loss could be demonstrated. Poststudy data were included in the analyses, extending maximum follow-up to 17 years. Results: After 17 years, 37 patients had developed glaucomatous visual field defects. When applying univariate Cox regression analyses, mean IOP of all measurements during the prospective part of the study was a significant risk factor for developing glaucoma (95% confidence interval [CI] 1.08 - 1.39), while IOP fluctuations were almost significant ( 95% CI 0.98 - 1.93). When separating effects of mean IOP level and mean IOP fluctuation using Cox multiple regression analysis, only IOP level came out as significant ( 95% CI 1.09 - 1.38), and IOP fluctuations did not contribute to the risk ( 95% CI 0.80 - 1.60). IOP fluctuation depended linearly on IOP level ( p< 0.0001), i.e. IOP fluctuation was larger in eyes with higher IOP levels. Conclusion: IOP fluctuations were not an independent risk factor for the incidence of glaucomatous visual field loss in subjects with ocular hypertension. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
risk factor, ocular hypertension, IOP fluctuation, glaucoma
in
Graefe's Archive for Clinical and Experimental Ophthalmology
volume
243
issue
Mar 9
pages
513 - 518
publisher
Springer
external identifiers
  • wos:000229903600002
  • scopus:22144436322
ISSN
1435-702X
DOI
10.1007/s00417-004-1103-8
language
English
LU publication?
yes
id
70806a96-cabf-4ab0-a975-6ffefa6aa63d (old id 135096)
alternative location
http://www.springerlink.com/content/wwu88t820072p435/
date added to LUP
2007-07-11 16:24:52
date last changed
2017-10-22 04:47:38
@article{70806a96-cabf-4ab0-a975-6ffefa6aa63d,
  abstract     = {Purpose: To establish whether intraocular pressure (IOP) fluctuations contribute to the risk of developing glaucoma in patients with high-risk ocular hypertension. Methods: Ninety patients included in the Malmo Ocular Hypertension Study were examined every 3 months with office-hours diurnal tension curves and computerised perimetry. Patients were followed up prospectively for 10 years or until glaucomatous visual field loss could be demonstrated. Poststudy data were included in the analyses, extending maximum follow-up to 17 years. Results: After 17 years, 37 patients had developed glaucomatous visual field defects. When applying univariate Cox regression analyses, mean IOP of all measurements during the prospective part of the study was a significant risk factor for developing glaucoma (95% confidence interval [CI] 1.08 - 1.39), while IOP fluctuations were almost significant ( 95% CI 0.98 - 1.93). When separating effects of mean IOP level and mean IOP fluctuation using Cox multiple regression analysis, only IOP level came out as significant ( 95% CI 1.09 - 1.38), and IOP fluctuations did not contribute to the risk ( 95% CI 0.80 - 1.60). IOP fluctuation depended linearly on IOP level ( p&lt; 0.0001), i.e. IOP fluctuation was larger in eyes with higher IOP levels. Conclusion: IOP fluctuations were not an independent risk factor for the incidence of glaucomatous visual field loss in subjects with ocular hypertension.},
  author       = {Bengtsson, Boel and Heijl, Anders},
  issn         = {1435-702X},
  keyword      = {risk factor,ocular hypertension,IOP fluctuation,glaucoma},
  language     = {eng},
  number       = {Mar 9},
  pages        = {513--518},
  publisher    = {Springer},
  series       = {Graefe's Archive for Clinical and Experimental Ophthalmology},
  title        = {Diurnal IOP fluctuation: not an independent risk factor for glaucomatous visual field loss in high-risk ocular hypertension.},
  url          = {http://dx.doi.org/10.1007/s00417-004-1103-8},
  volume       = {243},
  year         = {2005},
}