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Micro- and nanofluidics for DNA analysis

Tegenfeldt, Jonas LU orcid ; Prinz, Christelle LU ; Cao, H ; Huang, RL ; Austin, RH ; Chou, SY ; Cox, EC and Sturm, JC (2004) In Analytical and Bioanalytical Chemistry 378(7). p.1678-1692
Abstract
Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of... (More)
Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Bioanalytical Chemistry
volume
378
issue
7
pages
1678 - 1692
publisher
Springer
external identifiers
  • pmid:15007591
  • wos:000220458400004
  • scopus:12844260686
ISSN
1618-2642
DOI
10.1007/s00216-004-2526-0
language
English
LU publication?
yes
id
13517fa7-1b10-478a-90b3-1226d3816eb4 (old id 284112)
date added to LUP
2016-04-01 12:26:02
date last changed
2022-02-11 06:53:17
@article{13517fa7-1b10-478a-90b3-1226d3816eb4,
  abstract     = {{Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules.}},
  author       = {{Tegenfeldt, Jonas and Prinz, Christelle and Cao, H and Huang, RL and Austin, RH and Chou, SY and Cox, EC and Sturm, JC}},
  issn         = {{1618-2642}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1678--1692}},
  publisher    = {{Springer}},
  series       = {{Analytical and Bioanalytical Chemistry}},
  title        = {{Micro- and nanofluidics for DNA analysis}},
  url          = {{http://dx.doi.org/10.1007/s00216-004-2526-0}},
  doi          = {{10.1007/s00216-004-2526-0}},
  volume       = {{378}},
  year         = {{2004}},
}