Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden.
(2007) In Journal of Diabetes and its Complications 21(4). p.246-251- Abstract
- Objective: To investigate the relationship between early-onset retinopathy and urinary markers of renal dysfunction. Research Design and Methods: The Diabetes Incidence Study in Sweden (DISS) aims to register all new cases of diabetes in young adults (15-34 years). In 1987-1988, 806 patients were reported and later invited to participate in a follow-up study focusing on microvascular complications after similar to 10 years of diabetes. In the present study, 149 patients with type I diabetes, completed eye examination, and urine sampling were included. Results: The patients with retinopathy (n=58, 39%) had higher HbA(1c), (P<.001) and urinary IgG2/creatinine (P<.05) and IgG2/IgG4 ratios (P<.05). Patients with maculopathy had the... (More)
- Objective: To investigate the relationship between early-onset retinopathy and urinary markers of renal dysfunction. Research Design and Methods: The Diabetes Incidence Study in Sweden (DISS) aims to register all new cases of diabetes in young adults (15-34 years). In 1987-1988, 806 patients were reported and later invited to participate in a follow-up study focusing on microvascular complications after similar to 10 years of diabetes. In the present study, 149 patients with type I diabetes, completed eye examination, and urine sampling were included. Results: The patients with retinopathy (n=58, 39%) had higher HbA(1c), (P<.001) and urinary IgG2/creatinine (P<.05) and IgG2/IgG4 ratios (P<.05). Patients with maculopathy had the highest levels. No significant differences in urinary albumin/creatinine, glycosaminoglycans (GAGs)/creatinine, Tamm-Horsfall protein (THP)/creatinine, and IgG4/creatinine ratios were found. Women had higher urinary albumin/ creatinine (P<.01) and urinary IgG2/creatinine ratios (P<.01) than men. Conclusions: Young adults with type I diabetes and early-onset retinopathy had higher IgG2/creatinine and IgG2/IgG4 ratios than patients without retinopathy indicating that retinopathy is associated with a change in glomerular size selectivity. This was found in association with normal urinary albumin and THP excretion and may be suspected to reflect early general vascular changes. (C) 2007 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/540961
- author
- Torffvit, Ole LU ; Eriksson, Jan W ; Henricsson, Marianne LU ; Sundkvist, Göran LU ; Arnqvist, Hans J ; Blohmé, Goran ; Bolinder, Jan ; Nystrom, Lennarth ; Ostman, Jan and Svensson, Maria
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- IgG2 and IgG4, immurroglobulin, glycosaminoglycans, size selectivity, Tamm-Horsfall protein, transforming, glomerular, growth factor (TGF beta 1), diabetic retinopathy
- in
- Journal of Diabetes and its Complications
- volume
- 21
- issue
- 4
- pages
- 246 - 251
- publisher
- Elsevier
- external identifiers
-
- wos:000248166100007
- scopus:34347260646
- ISSN
- 1873-460X
- DOI
- 10.1016/j.jdiacomp.2006.01.002
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Section I-II (013230011), Medicine (Lund) (013230025), Diabetes Epidemiology and Neuropathy (013241560), Ophthalmology (013242810), Department of Nephrology (013230024)
- id
- 13551d1d-b93f-4ea0-9dec-094d88c754ce (old id 540961)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17616355&dopt=Abstract
- date added to LUP
- 2016-04-01 16:22:03
- date last changed
- 2024-01-11 06:42:12
@article{13551d1d-b93f-4ea0-9dec-094d88c754ce,
abstract = {{Objective: To investigate the relationship between early-onset retinopathy and urinary markers of renal dysfunction. Research Design and Methods: The Diabetes Incidence Study in Sweden (DISS) aims to register all new cases of diabetes in young adults (15-34 years). In 1987-1988, 806 patients were reported and later invited to participate in a follow-up study focusing on microvascular complications after similar to 10 years of diabetes. In the present study, 149 patients with type I diabetes, completed eye examination, and urine sampling were included. Results: The patients with retinopathy (n=58, 39%) had higher HbA(1c), (P<.001) and urinary IgG2/creatinine (P<.05) and IgG2/IgG4 ratios (P<.05). Patients with maculopathy had the highest levels. No significant differences in urinary albumin/creatinine, glycosaminoglycans (GAGs)/creatinine, Tamm-Horsfall protein (THP)/creatinine, and IgG4/creatinine ratios were found. Women had higher urinary albumin/ creatinine (P<.01) and urinary IgG2/creatinine ratios (P<.01) than men. Conclusions: Young adults with type I diabetes and early-onset retinopathy had higher IgG2/creatinine and IgG2/IgG4 ratios than patients without retinopathy indicating that retinopathy is associated with a change in glomerular size selectivity. This was found in association with normal urinary albumin and THP excretion and may be suspected to reflect early general vascular changes. (C) 2007 Elsevier Inc. All rights reserved.}},
author = {{Torffvit, Ole and Eriksson, Jan W and Henricsson, Marianne and Sundkvist, Göran and Arnqvist, Hans J and Blohmé, Goran and Bolinder, Jan and Nystrom, Lennarth and Ostman, Jan and Svensson, Maria}},
issn = {{1873-460X}},
keywords = {{IgG2 and IgG4; immurroglobulin; glycosaminoglycans; size selectivity; Tamm-Horsfall protein; transforming; glomerular; growth factor (TGF beta 1); diabetic retinopathy}},
language = {{eng}},
number = {{4}},
pages = {{246--251}},
publisher = {{Elsevier}},
series = {{Journal of Diabetes and its Complications}},
title = {{Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden.}},
url = {{https://lup.lub.lu.se/search/files/4651272/626075.pdf}},
doi = {{10.1016/j.jdiacomp.2006.01.002}},
volume = {{21}},
year = {{2007}},
}