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Design of robust preparative chromatography

Degerman, Marcus LU (2009)
Abstract
This work presents a methodology for analyzing and optimizing preparative chromatographic processes. It uses a model-based approach to find the critical process parameters, analyze the control space and suggest a design space that can be registered with the regulatory agencies. The methodology starts with a method for model calibration and validation. The model is then used to find an optimal operating point for an ideal scenario without process disturbances. Process disturbances are then added and the operating point is moved to a more robust one so that the process has a high overall performance. Sample-based uncertainty analysis can be used to estimate the probability of batch failure at a point or to determine robust UV cut points such... (More)
This work presents a methodology for analyzing and optimizing preparative chromatographic processes. It uses a model-based approach to find the critical process parameters, analyze the control space and suggest a design space that can be registered with the regulatory agencies. The methodology starts with a method for model calibration and validation. The model is then used to find an optimal operating point for an ideal scenario without process disturbances. Process disturbances are then added and the operating point is moved to a more robust one so that the process has a high overall performance. Sample-based uncertainty analysis can be used to estimate the probability of batch failure at a point or to determine robust UV cut points such that no batches will fail due to process disturbances. These same simulations can also be used to determine the critical process parameters.

The methodology is then extended to define a design space. This is done by defining the design space by optimal operating points for different scenarios. This means that the process can be optimized for future changes in cost and process parameters. This gives a limited set of operating points to be validated and registered with the regulatory agencies. The method can also be used to determine the benefits of reducing the process disturbances at a particular operating point. This provides decision support when determining the quality of process equipment that is required, as higher quality equipment will require a larger investment. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Mota, JosĂ© Paulo, Universidade Nova de Lisbo, Portugal
organization
publishing date
type
Thesis
publication status
published
subject
keywords
sensitivity analysis, optimization, modeling, preparative chromatography, Design space, Control Space, uncertainty analysis
pages
63 pages
publisher
Department of Chemical Engineering, Lund University
defense location
Lecture hall B, Center for Chemistry and Chemical Engineering, Getingevägen 60, Lund University Faculty of Engineering
defense date
2009-05-08 13:30
ISSN
1100-2778
ISBN
978-91-628-7732-3
language
English
LU publication?
yes
id
db70a31e-573b-40fe-8c42-f4d9e4eb17a0 (old id 1359911)
date added to LUP
2009-03-20 14:31:05
date last changed
2016-09-19 08:44:45
@phdthesis{db70a31e-573b-40fe-8c42-f4d9e4eb17a0,
  abstract     = {This work presents a methodology for analyzing and optimizing preparative chromatographic processes. It uses a model-based approach to find the critical process parameters, analyze the control space and suggest a design space that can be registered with the regulatory agencies. The methodology starts with a method for model calibration and validation. The model is then used to find an optimal operating point for an ideal scenario without process disturbances. Process disturbances are then added and the operating point is moved to a more robust one so that the process has a high overall performance. Sample-based uncertainty analysis can be used to estimate the probability of batch failure at a point or to determine robust UV cut points such that no batches will fail due to process disturbances. These same simulations can also be used to determine the critical process parameters.<br/><br>
The methodology is then extended to define a design space. This is done by defining the design space by optimal operating points for different scenarios. This means that the process can be optimized for future changes in cost and process parameters. This gives a limited set of operating points to be validated and registered with the regulatory agencies. The method can also be used to determine the benefits of reducing the process disturbances at a particular operating point. This provides decision support when determining the quality of process equipment that is required, as higher quality equipment will require a larger investment.},
  author       = {Degerman, Marcus},
  isbn         = {978-91-628-7732-3},
  issn         = {1100-2778},
  keyword      = {sensitivity analysis,optimization,modeling,preparative chromatography,Design space,Control Space,uncertainty analysis},
  language     = {eng},
  pages        = {63},
  publisher    = {Department of Chemical Engineering, Lund University},
  school       = {Lund University},
  title        = {Design of robust preparative chromatography},
  year         = {2009},
}