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Incident coronary events and case fatality in relation to common carotid intima-media thickness.

Rosvall, Maria LU ; Janzon, Lars LU ; Berglund, Göran LU ; Engström, Gunnar LU and Hedblad, Bo LU (2005) In Journal of Internal Medicine 257(5). p.430-437
Abstract
Objectives. To evaluate the incidence of coronary events (CE) and case fatality in relation to common carotid intima-media thickness (IMT) and carotid plaque over a median follow up of 7 years.



Subjects. A total of 5163 Swedish middle-aged men and women with no prior myocardial infarction and/or stroke.



Methods and results. The associations amongst B-mode ultrasound determined common carotid IMT, carotid plaque (focal IMT > 1.2 mm) and carotid stenosis (lumen reduction of >15%) and incident CE, were investigated in relation to cardiovascular risk factor levels. Age- and sex-adjusted common carotid IMT, carotid plaque and carotid stenosis were significantly (P < 0.05) related to future CE.... (More)
Objectives. To evaluate the incidence of coronary events (CE) and case fatality in relation to common carotid intima-media thickness (IMT) and carotid plaque over a median follow up of 7 years.



Subjects. A total of 5163 Swedish middle-aged men and women with no prior myocardial infarction and/or stroke.



Methods and results. The associations amongst B-mode ultrasound determined common carotid IMT, carotid plaque (focal IMT > 1.2 mm) and carotid stenosis (lumen reduction of >15%) and incident CE, were investigated in relation to cardiovascular risk factor levels. Age- and sex-adjusted common carotid IMT, carotid plaque and carotid stenosis were significantly (P < 0.05) related to future CE. Adjustment for established risk factors generally reduced the hazard rate ratios. However, the continuous measure of common carotid IMT, carotid plaque and carotid stenosis were significantly related to incident CE, even after risk factor adjustment. The strength of the associations between common carotid IMT and CE was only to a small extent reduced after adjustment for presence of carotid plaque. There were no statistically significant associations between common carotid IMT, carotid plaque or carotid stenosis and short-term case-fatality rates (28-days mortality) or long-term case-fatality rates (5-years mortality).



Conclusions. The results show an association between common carotid IMT and incident CE, independently of cardiovascular risk factors and carotid plaque. However, there was no association with short-term or long-term mortality after a CE. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
257
issue
5
pages
430 - 437
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • pmid:15836659
  • wos:000228396700005
  • scopus:18044365616
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2005.01485.x
language
English
LU publication?
yes
id
11b17acc-e21b-45c3-a9ac-5a065aac84a9 (old id 136165)
date added to LUP
2007-07-25 08:08:03
date last changed
2017-10-29 04:20:45
@article{11b17acc-e21b-45c3-a9ac-5a065aac84a9,
  abstract     = {Objectives. To evaluate the incidence of coronary events (CE) and case fatality in relation to common carotid intima-media thickness (IMT) and carotid plaque over a median follow up of 7 years.<br/><br>
<br/><br>
Subjects. A total of 5163 Swedish middle-aged men and women with no prior myocardial infarction and/or stroke.<br/><br>
<br/><br>
Methods and results. The associations amongst B-mode ultrasound determined common carotid IMT, carotid plaque (focal IMT &gt; 1.2 mm) and carotid stenosis (lumen reduction of &gt;15%) and incident CE, were investigated in relation to cardiovascular risk factor levels. Age- and sex-adjusted common carotid IMT, carotid plaque and carotid stenosis were significantly (P &lt; 0.05) related to future CE. Adjustment for established risk factors generally reduced the hazard rate ratios. However, the continuous measure of common carotid IMT, carotid plaque and carotid stenosis were significantly related to incident CE, even after risk factor adjustment. The strength of the associations between common carotid IMT and CE was only to a small extent reduced after adjustment for presence of carotid plaque. There were no statistically significant associations between common carotid IMT, carotid plaque or carotid stenosis and short-term case-fatality rates (28-days mortality) or long-term case-fatality rates (5-years mortality).<br/><br>
<br/><br>
Conclusions. The results show an association between common carotid IMT and incident CE, independently of cardiovascular risk factors and carotid plaque. However, there was no association with short-term or long-term mortality after a CE.},
  author       = {Rosvall, Maria and Janzon, Lars and Berglund, Göran and Engström, Gunnar and Hedblad, Bo},
  issn         = {1365-2796},
  language     = {eng},
  number       = {5},
  pages        = {430--437},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Incident coronary events and case fatality in relation to common carotid intima-media thickness.},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2005.01485.x},
  volume       = {257},
  year         = {2005},
}