Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Peptide-imprinted polymer microspheres prepared by precipitation polymerization using a single bi-functional monomer.

Yoshimatsu, Keiichi LU ; LeJeune, Jason ; Spivak, David A and Ye, Lei LU orcid (2009) In Analyst 134(4). p.719-724
Abstract
A single bi-functional monomer, N,O-bismethacryloyl ethanolamine (NOBE), was used in precipitation polymerization system to synthesize molecularly imprinted polymer (MIP) microspheres. Highly specific binding sites were obtained for N-terminal protected neuropeptides, Boc-Leu-enkephalin and Pyr-Leu-enkephalin. The use of NOBE allowed binding sites to be formed in polymer microspheres that are able to recognize target peptides through the consensus C-terminal sequence. The interesting molecular binding results suggest a new approach for peptide analysis combining in situ chemical modification with MIP recognition under non-aqueous conditions.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analyst
volume
134
issue
4
pages
719 - 724
publisher
Royal Society of Chemistry
external identifiers
  • wos:000264482300012
  • pmid:19305921
  • scopus:67149089150
ISSN
1364-5528
DOI
10.1039/b814967d
language
English
LU publication?
yes
id
f3e41eb5-b909-4f87-a2f4-b283da83a033 (old id 1367569)
date added to LUP
2016-04-01 14:32:36
date last changed
2025-01-04 01:50:27
@article{f3e41eb5-b909-4f87-a2f4-b283da83a033,
  abstract     = {{A single bi-functional monomer, N,O-bismethacryloyl ethanolamine (NOBE), was used in precipitation polymerization system to synthesize molecularly imprinted polymer (MIP) microspheres. Highly specific binding sites were obtained for N-terminal protected neuropeptides, Boc-Leu-enkephalin and Pyr-Leu-enkephalin. The use of NOBE allowed binding sites to be formed in polymer microspheres that are able to recognize target peptides through the consensus C-terminal sequence. The interesting molecular binding results suggest a new approach for peptide analysis combining in situ chemical modification with MIP recognition under non-aqueous conditions.}},
  author       = {{Yoshimatsu, Keiichi and LeJeune, Jason and Spivak, David A and Ye, Lei}},
  issn         = {{1364-5528}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{719--724}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Analyst}},
  title        = {{Peptide-imprinted polymer microspheres prepared by precipitation polymerization using a single bi-functional monomer.}},
  url          = {{http://dx.doi.org/10.1039/b814967d}},
  doi          = {{10.1039/b814967d}},
  volume       = {{134}},
  year         = {{2009}},
}