Inflammatory activity increases with haemoglobin A(1)c in patients with acute coronary syndrome.
(2009) In Scandinavian cardiovascular journal : SCJ 43(6). p.380-385- Abstract
- Objective. To study the relationship between inflammation, diabetes and HbA(1)c levels in patients with acute coronary syndrome (ACS). Design. Single-centre cross-sectional study comprising 688 consecutive patients with ACS (108 with diabetes) and 341 with stable coronary artery disease (SCAD) (51 with diabetes). High-sensitive C-reactive protein (hsCRP), albumin and fibrinogen concentrations, erythrocyte sedimentation rates (ESR) and leukocyte counts were measured. Results. hsCRP, fibrinogen and ESR levels were higher and albumin lower in ACS patients. ESR was higher, albumin lower and hsCRP borderline significantly higher (p=0.053) in ACS patient with diabetes compared to those without. All inflammatory markers were associated with... (More)
- Objective. To study the relationship between inflammation, diabetes and HbA(1)c levels in patients with acute coronary syndrome (ACS). Design. Single-centre cross-sectional study comprising 688 consecutive patients with ACS (108 with diabetes) and 341 with stable coronary artery disease (SCAD) (51 with diabetes). High-sensitive C-reactive protein (hsCRP), albumin and fibrinogen concentrations, erythrocyte sedimentation rates (ESR) and leukocyte counts were measured. Results. hsCRP, fibrinogen and ESR levels were higher and albumin lower in ACS patients. ESR was higher, albumin lower and hsCRP borderline significantly higher (p=0.053) in ACS patient with diabetes compared to those without. All inflammatory markers were associated with HbA(1)c in all 688 ACS patients as well as in 540 non-diabetic ACS patients with normal HbA(1)c. In multivariate analyses, all inflammatory markers were independently associated with HbA(1)c in the entire ACS group, regardless of diabetes being present or not. When non-diabetic ACS patients were analyzed separately, only ESR and leukocyte counts were independently correlated with HbA(1)c. Conclusions. Patients with ACS had increased inflammatory activity, which increased with HbA(1)c levels in patients who neither had a history of diabetes nor HbA(1)c above normal, and was further exaggerated in the presence of diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367731
- author
- Gustavsson, Carl Gunnar LU and Agardh, Carl-David LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian cardiovascular journal : SCJ
- volume
- 43
- issue
- 6
- pages
- 380 - 385
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000272974500005
- pmid:19291585
- scopus:72049129942
- pmid:19291585
- ISSN
- 1651-2006
- DOI
- 10.1080/14017430902822999
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Department of Clinical Sciences, Malmö (013240000)
- id
- 0a8e3066-4bb8-4edf-8fe7-b1769e5f6b2f (old id 1367731)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19291585?dopt=Abstract
- http://informahealthcare.com/doi/abs/10.1080/14017430902822999
- date added to LUP
- 2016-04-04 09:27:51
- date last changed
- 2022-01-29 18:00:11
@article{0a8e3066-4bb8-4edf-8fe7-b1769e5f6b2f, abstract = {{Objective. To study the relationship between inflammation, diabetes and HbA(1)c levels in patients with acute coronary syndrome (ACS). Design. Single-centre cross-sectional study comprising 688 consecutive patients with ACS (108 with diabetes) and 341 with stable coronary artery disease (SCAD) (51 with diabetes). High-sensitive C-reactive protein (hsCRP), albumin and fibrinogen concentrations, erythrocyte sedimentation rates (ESR) and leukocyte counts were measured. Results. hsCRP, fibrinogen and ESR levels were higher and albumin lower in ACS patients. ESR was higher, albumin lower and hsCRP borderline significantly higher (p=0.053) in ACS patient with diabetes compared to those without. All inflammatory markers were associated with HbA(1)c in all 688 ACS patients as well as in 540 non-diabetic ACS patients with normal HbA(1)c. In multivariate analyses, all inflammatory markers were independently associated with HbA(1)c in the entire ACS group, regardless of diabetes being present or not. When non-diabetic ACS patients were analyzed separately, only ESR and leukocyte counts were independently correlated with HbA(1)c. Conclusions. Patients with ACS had increased inflammatory activity, which increased with HbA(1)c levels in patients who neither had a history of diabetes nor HbA(1)c above normal, and was further exaggerated in the presence of diabetes.}}, author = {{Gustavsson, Carl Gunnar and Agardh, Carl-David}}, issn = {{1651-2006}}, language = {{eng}}, number = {{6}}, pages = {{380--385}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian cardiovascular journal : SCJ}}, title = {{Inflammatory activity increases with haemoglobin A(1)c in patients with acute coronary syndrome.}}, url = {{http://dx.doi.org/10.1080/14017430902822999}}, doi = {{10.1080/14017430902822999}}, volume = {{43}}, year = {{2009}}, }