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Haemodynamic effects of -75 mmHg negative pressure therapy in a porcine sternotomy wound model.

Mokhtari, Arash LU ; Gustafsson, Ronny LU ; Sjögren, Johan LU ; Nilsson, Johan LU ; Lindstedt Ingemansson, Sandra LU ; Malmsjö, Malin LU and Ingemansson, Richard LU (2009) In International Wound Journal 6(1). p.48-54
Abstract
Previous research has shown -125 mmHg to be the optimal negative pressure for creating an environment that promotes wound healing, and this has therefore been adopted as a standard pressure for patients with deep sternal wound infection. However, it has not yet been clearly shown that -125 mmHg is the optimal pressure from a haemodynamic point of view. Furthermore, there have been reports of cardiac rupture during -125 mmHg negative pressure therapy. We therefore studied the effects of a lower pressure: -75 mmHg. Twelve pigs were used. After median sternotomy, sealed negative pressure therapy of -75 mmHg was applied. Baseline measurements were made and continuous recording of the cardiac output, end-tidal CO(2) production, mean arterial... (More)
Previous research has shown -125 mmHg to be the optimal negative pressure for creating an environment that promotes wound healing, and this has therefore been adopted as a standard pressure for patients with deep sternal wound infection. However, it has not yet been clearly shown that -125 mmHg is the optimal pressure from a haemodynamic point of view. Furthermore, there have been reports of cardiac rupture during -125 mmHg negative pressure therapy. We therefore studied the effects of a lower pressure: -75 mmHg. Twelve pigs were used. After median sternotomy, sealed negative pressure therapy of -75 mmHg was applied. Baseline measurements were made and continuous recording of the cardiac output, end-tidal CO(2) production, mean arterial pressure, mean pulmonary pressure (pulmonary artery pressure), systemic vascular resistance, pulmonary vascular resistance, left atrial pressure and central venous pressure was started. Six pigs served as controls. No statistically significant difference was observed in any of the haemodynamic parameters studied, compared with the controls. The present study shows that, with a suitable foam application technique, -75 mmHg can be applied without compromising the central haemodynamics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Wound Journal
volume
6
issue
1
pages
48 - 54
publisher
Wiley-Blackwell
external identifiers
  • wos:000207845700007
  • pmid:19291115
  • scopus:61849119170
ISSN
1742-481X
DOI
10.1111/j.1742-481X.2008.00566.x
language
English
LU publication?
yes
id
b0c650b5-5238-486e-8fdd-30de2ceeb5cf (old id 1367754)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19291115?dopt=Abstract
date added to LUP
2009-04-08 10:55:51
date last changed
2017-01-01 07:29:18
@article{b0c650b5-5238-486e-8fdd-30de2ceeb5cf,
  abstract     = {Previous research has shown -125 mmHg to be the optimal negative pressure for creating an environment that promotes wound healing, and this has therefore been adopted as a standard pressure for patients with deep sternal wound infection. However, it has not yet been clearly shown that -125 mmHg is the optimal pressure from a haemodynamic point of view. Furthermore, there have been reports of cardiac rupture during -125 mmHg negative pressure therapy. We therefore studied the effects of a lower pressure: -75 mmHg. Twelve pigs were used. After median sternotomy, sealed negative pressure therapy of -75 mmHg was applied. Baseline measurements were made and continuous recording of the cardiac output, end-tidal CO(2) production, mean arterial pressure, mean pulmonary pressure (pulmonary artery pressure), systemic vascular resistance, pulmonary vascular resistance, left atrial pressure and central venous pressure was started. Six pigs served as controls. No statistically significant difference was observed in any of the haemodynamic parameters studied, compared with the controls. The present study shows that, with a suitable foam application technique, -75 mmHg can be applied without compromising the central haemodynamics.},
  author       = {Mokhtari, Arash and Gustafsson, Ronny and Sjögren, Johan and Nilsson, Johan and Lindstedt Ingemansson, Sandra and Malmsjö, Malin and Ingemansson, Richard},
  issn         = {1742-481X},
  language     = {eng},
  number       = {1},
  pages        = {48--54},
  publisher    = {Wiley-Blackwell},
  series       = {International Wound Journal},
  title        = {Haemodynamic effects of -75 mmHg negative pressure therapy in a porcine sternotomy wound model.},
  url          = {http://dx.doi.org/10.1111/j.1742-481X.2008.00566.x},
  volume       = {6},
  year         = {2009},
}