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Genome-wide association study for type 2 diabetes: clinical applications.

Lyssenko, Valeriya LU and Groop, Leif LU (2009) In Current Opinion in Lipidology 20(2). p.87-91
Abstract
PURPOSE OF REVIEW: Dissecting the genetics of complex polygenic diseases in which environmental factors interact with genetic variants in the predisposition to the disease has not been a trivial task and success has been limited. The purpose of this review is to provide insights into recent advances in genetics of type 2 diabetes. RECENT FINDINGS: In the past year, together the consortia of several genome-wide association studies for type 2 diabetes have identified 19 common variants increasing susceptibility to disease. Most novel loci seem to influence the capacity of beta-cells to increase insulin secretion in response to increase in insulin resistance or body weight. Combined genetic information ultimately might aid in personalized... (More)
PURPOSE OF REVIEW: Dissecting the genetics of complex polygenic diseases in which environmental factors interact with genetic variants in the predisposition to the disease has not been a trivial task and success has been limited. The purpose of this review is to provide insights into recent advances in genetics of type 2 diabetes. RECENT FINDINGS: In the past year, together the consortia of several genome-wide association studies for type 2 diabetes have identified 19 common variants increasing susceptibility to disease. Most novel loci seem to influence the capacity of beta-cells to increase insulin secretion in response to increase in insulin resistance or body weight. Combined genetic information ultimately might aid in personalized prediction of disease risk; however, genetic tests cannot be offered yet to predict disease. The main reason is that the increased risk associated with each risk variant is small. We have only begun to explore the role of rare variants with stronger effects or copy number variations in the pathogenesis of type 2 diabetes. SUMMARY: Rapid progress in the genetics of type 2 diabetes has significantly improved our understanding of disease pathogenesis and provided promising opportunities for drug discoveries over the coming years. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Lipidology
volume
20
issue
2
pages
87 - 91
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000264956600001
  • pmid:19276887
  • scopus:64549105734
ISSN
1473-6535
DOI
10.1097/MOL.0b013e32832923af
language
English
LU publication?
yes
id
88941d35-d2de-41ed-90b4-da5391268611 (old id 1367872)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19276887?dopt=Abstract
date added to LUP
2009-04-07 16:21:13
date last changed
2017-06-04 04:32:42
@article{88941d35-d2de-41ed-90b4-da5391268611,
  abstract     = {PURPOSE OF REVIEW: Dissecting the genetics of complex polygenic diseases in which environmental factors interact with genetic variants in the predisposition to the disease has not been a trivial task and success has been limited. The purpose of this review is to provide insights into recent advances in genetics of type 2 diabetes. RECENT FINDINGS: In the past year, together the consortia of several genome-wide association studies for type 2 diabetes have identified 19 common variants increasing susceptibility to disease. Most novel loci seem to influence the capacity of beta-cells to increase insulin secretion in response to increase in insulin resistance or body weight. Combined genetic information ultimately might aid in personalized prediction of disease risk; however, genetic tests cannot be offered yet to predict disease. The main reason is that the increased risk associated with each risk variant is small. We have only begun to explore the role of rare variants with stronger effects or copy number variations in the pathogenesis of type 2 diabetes. SUMMARY: Rapid progress in the genetics of type 2 diabetes has significantly improved our understanding of disease pathogenesis and provided promising opportunities for drug discoveries over the coming years.},
  author       = {Lyssenko, Valeriya and Groop, Leif},
  issn         = {1473-6535},
  language     = {eng},
  number       = {2},
  pages        = {87--91},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Lipidology},
  title        = {Genome-wide association study for type 2 diabetes: clinical applications.},
  url          = {http://dx.doi.org/10.1097/MOL.0b013e32832923af},
  volume       = {20},
  year         = {2009},
}