Coated formulations: New insights into the release mechanism and changes in the film properties with a novel release cell.
(2009) In Journal of Controlled Release 136. p.206-212- Abstract
- The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when they were immersed in a phosphate buffer solution. The release mechanism of potassium nitrate through EC/HPC-LF films containing 20, 24 and 30% HPC-LF was elucidated in a new release cell equipped with a manometer to measure the pressure build-up inside the cell. A lag phase in the release accompanied by a pressure build-up was observable in all... (More)
- The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when they were immersed in a phosphate buffer solution. The release mechanism of potassium nitrate through EC/HPC-LF films containing 20, 24 and 30% HPC-LF was elucidated in a new release cell equipped with a manometer to measure the pressure build-up inside the cell. A lag phase in the release accompanied by a pressure build-up was observable in all the experiments showing that all the films were initially semi-permeable to KNO(3). However, pressure data revealed that films with 30% HPC-LF became permeable to KNO(3) during the release process due to HPC-LF leaching. Importantly, the blend ratio influenced not only the release rate (which increased as the amount of HPC-LF increased), and the lag time (which increased as the amount of HPC-LF decreased), but also the release mechanism, which changed from osmotic pumping to diffusion as the amount of HPC-LF increased. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/1368129
- author
- Marucci, Mariagrazia LU ; Hjärtstam, Johan; Ragnarsson, Gert; Iselau, Frida and Axelsson, Anders LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Controlled Release
- volume
- 136
- pages
- 206 - 212
- publisher
- Elsevier
- external identifiers
-
- wos:000267561200006
- pmid:19250954
- scopus:67349186207
- ISSN
- 1873-4995
- DOI
- 10.1016/j.jconrel.2009.02.017
- language
- English
- LU publication?
- yes
- id
- 9234cf9b-6458-46de-8217-8ca8810abd62 (old id 1368129)
- date added to LUP
- 2009-04-07 07:37:04
- date last changed
- 2018-02-25 03:17:18
@article{9234cf9b-6458-46de-8217-8ca8810abd62, abstract = {The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when they were immersed in a phosphate buffer solution. The release mechanism of potassium nitrate through EC/HPC-LF films containing 20, 24 and 30% HPC-LF was elucidated in a new release cell equipped with a manometer to measure the pressure build-up inside the cell. A lag phase in the release accompanied by a pressure build-up was observable in all the experiments showing that all the films were initially semi-permeable to KNO(3). However, pressure data revealed that films with 30% HPC-LF became permeable to KNO(3) during the release process due to HPC-LF leaching. Importantly, the blend ratio influenced not only the release rate (which increased as the amount of HPC-LF increased), and the lag time (which increased as the amount of HPC-LF decreased), but also the release mechanism, which changed from osmotic pumping to diffusion as the amount of HPC-LF increased.}, author = {Marucci, Mariagrazia and Hjärtstam, Johan and Ragnarsson, Gert and Iselau, Frida and Axelsson, Anders}, issn = {1873-4995}, language = {eng}, pages = {206--212}, publisher = {Elsevier}, series = {Journal of Controlled Release}, title = {Coated formulations: New insights into the release mechanism and changes in the film properties with a novel release cell.}, url = {http://dx.doi.org/10.1016/j.jconrel.2009.02.017}, volume = {136}, year = {2009}, }