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Coated formulations: New insights into the release mechanism and changes in the film properties with a novel release cell.

Marucci, Mariagrazia LU ; Hjärtstam, Johan; Ragnarsson, Gert; Iselau, Frida and Axelsson, Anders LU (2009) In Journal of Controlled Release 136. p.206-212
Abstract
The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when they were immersed in a phosphate buffer solution. The release mechanism of potassium nitrate through EC/HPC-LF films containing 20, 24 and 30% HPC-LF was elucidated in a new release cell equipped with a manometer to measure the pressure build-up inside the cell. A lag phase in the release accompanied by a pressure build-up was observable in all... (More)
The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when they were immersed in a phosphate buffer solution. The release mechanism of potassium nitrate through EC/HPC-LF films containing 20, 24 and 30% HPC-LF was elucidated in a new release cell equipped with a manometer to measure the pressure build-up inside the cell. A lag phase in the release accompanied by a pressure build-up was observable in all the experiments showing that all the films were initially semi-permeable to KNO(3). However, pressure data revealed that films with 30% HPC-LF became permeable to KNO(3) during the release process due to HPC-LF leaching. Importantly, the blend ratio influenced not only the release rate (which increased as the amount of HPC-LF increased), and the lag time (which increased as the amount of HPC-LF decreased), but also the release mechanism, which changed from osmotic pumping to diffusion as the amount of HPC-LF increased. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Controlled Release
volume
136
pages
206 - 212
publisher
Elsevier
external identifiers
  • wos:000267561200006
  • pmid:19250954
  • scopus:67349186207
ISSN
1873-4995
DOI
10.1016/j.jconrel.2009.02.017
language
English
LU publication?
yes
id
9234cf9b-6458-46de-8217-8ca8810abd62 (old id 1368129)
date added to LUP
2009-04-07 07:37:04
date last changed
2017-01-01 04:20:29
@article{9234cf9b-6458-46de-8217-8ca8810abd62,
  abstract     = {The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when they were immersed in a phosphate buffer solution. The release mechanism of potassium nitrate through EC/HPC-LF films containing 20, 24 and 30% HPC-LF was elucidated in a new release cell equipped with a manometer to measure the pressure build-up inside the cell. A lag phase in the release accompanied by a pressure build-up was observable in all the experiments showing that all the films were initially semi-permeable to KNO(3). However, pressure data revealed that films with 30% HPC-LF became permeable to KNO(3) during the release process due to HPC-LF leaching. Importantly, the blend ratio influenced not only the release rate (which increased as the amount of HPC-LF increased), and the lag time (which increased as the amount of HPC-LF decreased), but also the release mechanism, which changed from osmotic pumping to diffusion as the amount of HPC-LF increased.},
  author       = {Marucci, Mariagrazia and Hjärtstam, Johan and Ragnarsson, Gert and Iselau, Frida and Axelsson, Anders},
  issn         = {1873-4995},
  language     = {eng},
  pages        = {206--212},
  publisher    = {Elsevier},
  series       = {Journal of Controlled Release},
  title        = {Coated formulations: New insights into the release mechanism and changes in the film properties with a novel release cell.},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2009.02.017},
  volume       = {136},
  year         = {2009},
}