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Brainstem and thalamic projections from a craniovascular sensory nervous centre in the rostral cervical spinal dorsal horn of rats.

Liu, Y; Broman, Jonas LU ; Zhang, Mengliang LU and Edvinsson, Lars LU (2009) In Cephalalgia 29. p.935-948
Abstract
To examine the ascending projections from the headache-related trigeminocervical complex in rats, biotinylated dextran amine (BDA) was injected into the ventrolateral dorsal horn of segments C1 and C2, a region previously demonstrated to receive input from sensory nerves in cranial blood vessels. Following injections into laminae I-II, BDA-labelled terminations were found bilaterally in several nuclei in the pons and the midbrain, including the pontine reticular nucleus, the parabrachial nuclei, the cuneiform nucleus and the periaqueductal grey. In the diencephalon, terminations were confined to the contralateral side and evident foremost in the posterior nuclear group, especially its triangular part, and in the ventral posteromedial... (More)
To examine the ascending projections from the headache-related trigeminocervical complex in rats, biotinylated dextran amine (BDA) was injected into the ventrolateral dorsal horn of segments C1 and C2, a region previously demonstrated to receive input from sensory nerves in cranial blood vessels. Following injections into laminae I-II, BDA-labelled terminations were found bilaterally in several nuclei in the pons and the midbrain, including the pontine reticular nucleus, the parabrachial nuclei, the cuneiform nucleus and the periaqueductal grey. In the diencephalon, terminations were confined to the contralateral side and evident foremost in the posterior nuclear group, especially its triangular part, and in the ventral posteromedial nucleus. Following injections extending through laminae I-IV, anterograde labelling was more extensive. Some of the above regions are likely to be involved in the central processing of noxious signals of craniovascular origin and therefore putatively involved in mechanisms associated with primary headaches. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cephalalgia
volume
29
pages
935 - 948
publisher
Wiley-Blackwell
external identifiers
  • wos:000268683800004
  • pmid:19250290
  • scopus:68249115581
ISSN
0333-1024
DOI
10.1111/j.1468-2982.2008.01829.x
language
English
LU publication?
yes
id
a1e4eee7-f143-4421-80a1-adea3e322d2d (old id 1368169)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19250290?dopt=Abstract
date added to LUP
2009-04-03 12:11:24
date last changed
2017-05-28 04:37:32
@article{a1e4eee7-f143-4421-80a1-adea3e322d2d,
  abstract     = {To examine the ascending projections from the headache-related trigeminocervical complex in rats, biotinylated dextran amine (BDA) was injected into the ventrolateral dorsal horn of segments C1 and C2, a region previously demonstrated to receive input from sensory nerves in cranial blood vessels. Following injections into laminae I-II, BDA-labelled terminations were found bilaterally in several nuclei in the pons and the midbrain, including the pontine reticular nucleus, the parabrachial nuclei, the cuneiform nucleus and the periaqueductal grey. In the diencephalon, terminations were confined to the contralateral side and evident foremost in the posterior nuclear group, especially its triangular part, and in the ventral posteromedial nucleus. Following injections extending through laminae I-IV, anterograde labelling was more extensive. Some of the above regions are likely to be involved in the central processing of noxious signals of craniovascular origin and therefore putatively involved in mechanisms associated with primary headaches.},
  author       = {Liu, Y and Broman, Jonas and Zhang, Mengliang and Edvinsson, Lars},
  issn         = {0333-1024},
  language     = {eng},
  pages        = {935--948},
  publisher    = {Wiley-Blackwell},
  series       = {Cephalalgia},
  title        = {Brainstem and thalamic projections from a craniovascular sensory nervous centre in the rostral cervical spinal dorsal horn of rats.},
  url          = {http://dx.doi.org/10.1111/j.1468-2982.2008.01829.x},
  volume       = {29},
  year         = {2009},
}