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The epidemic of methylisothiazolinone : A European prospective study

Schwensen, Jakob F.; Uter, Wolfgang; Bruze, Magnus LU ; Svedman, Cecilia LU ; Goossens, An; Wilkinson, Mark; Giménez Arnau, Ana; Gonçalo, Margarida; Andersen, Klaus E. and Paulsen, Evy, et al. (2017) In Contact Dermatitis 76(5). p.272-279
Abstract

Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Methods: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000ppm aq.). Results: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7%... (More)

Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Methods: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000ppm aq.). Results: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms. Conclusion: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.

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keywords
Allergic contact dermatitis, CAS no. 2682-20-4, Cosmetics, Exposure, Methylchloroisothiazolinone, Methylisothiazolinone
in
Contact Dermatitis
volume
76
issue
5
pages
272 - 279
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85007414683
  • wos:000398809600002
ISSN
0105-1873
DOI
10.1111/cod.12733
language
English
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yes
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136c73ce-a999-4e36-9ba5-d5e375ca265d
date added to LUP
2017-01-19 15:14:02
date last changed
2018-01-07 11:45:48
@article{136c73ce-a999-4e36-9ba5-d5e375ca265d,
  abstract     = {<p>Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Methods: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000ppm aq.). Results: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms. Conclusion: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.</p>},
  author       = {Schwensen, Jakob F. and Uter, Wolfgang and Bruze, Magnus and Svedman, Cecilia and Goossens, An and Wilkinson, Mark and Giménez Arnau, Ana and Gonçalo, Margarida and Andersen, Klaus E. and Paulsen, Evy and Agner, Tove and Foti, Caterina and Aalto-Korte, Kristiina and Mcfadden, John and White, Ian and Johansen, Jeanne D.},
  issn         = {0105-1873},
  keyword      = {Allergic contact dermatitis,CAS no. 2682-20-4,Cosmetics,Exposure,Methylchloroisothiazolinone,Methylisothiazolinone},
  language     = {eng},
  number       = {5},
  pages        = {272--279},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {The epidemic of methylisothiazolinone : A European prospective study},
  url          = {http://dx.doi.org/10.1111/cod.12733},
  volume       = {76},
  year         = {2017},
}