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Between-year variation of MHC allele frequencies in great reed warblers: selection or drift?

Westerdahl, Helena LU ; Hansson, Bengt LU ; Bensch, Staffan LU and Hasselquist, Dennis LU (2004) In Journal of Evolutionary Biology 17(3). p.485-492
Abstract
The major histocompatibility complex (MHC) genes are extremely polymorphic and this variation is assumed to be maintained by balancing selection. Cyclic interactions between pathogens and their hosts could generate such selection, and specific MHC alleles or heterozygosity at certain MHC loci have been shown to confer resistance against particular pathogens. Here we compare the temporal variation in allele frequencies of 23 MHC class I alleles with that of 23 neutral microsatellite markers in adult great reed warblers (a passerine bird) in nine successive cohorts. Overall, the MHC alleles showed a significantly higher variation in allele frequencies between cohorts than the microsatellite alleles, using a multi-variate genetic analysis... (More)
The major histocompatibility complex (MHC) genes are extremely polymorphic and this variation is assumed to be maintained by balancing selection. Cyclic interactions between pathogens and their hosts could generate such selection, and specific MHC alleles or heterozygosity at certain MHC loci have been shown to confer resistance against particular pathogens. Here we compare the temporal variation in allele frequencies of 23 MHC class I alleles with that of 23 neutral microsatellite markers in adult great reed warblers (a passerine bird) in nine successive cohorts. Overall, the MHC alleles showed a significantly higher variation in allele frequencies between cohorts than the microsatellite alleles, using a multi-variate genetic analysis (AMOVA). The frequency of two specific MHC alleles, A3e (P = 0.046) and B4b (P = 0.0018), varied more between cohorts than expected from random, whereas none of the microsatellite alleles showed fluctuations exceeding the expectation from stochastic variation. These results imply that the variation in MHC allele frequencies between cohorts is not a result of demographic events, but rather an effect of selection favouring different MHC alleles in different years. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Evolutionary Biology
volume
17
issue
3
pages
485 - 492
publisher
John Wiley & Sons
external identifiers
  • wos:000221197900002
  • pmid:15149391
  • scopus:2342560625
ISSN
1420-9101
DOI
10.1111/j.1420-9101.2004.00711.x
language
English
LU publication?
yes
id
e2dfaee4-4b03-4d34-a243-d7208f7340fe (old id 137037)
date added to LUP
2007-06-25 14:08:16
date last changed
2017-07-02 03:33:26
@article{e2dfaee4-4b03-4d34-a243-d7208f7340fe,
  abstract     = {The major histocompatibility complex (MHC) genes are extremely polymorphic and this variation is assumed to be maintained by balancing selection. Cyclic interactions between pathogens and their hosts could generate such selection, and specific MHC alleles or heterozygosity at certain MHC loci have been shown to confer resistance against particular pathogens. Here we compare the temporal variation in allele frequencies of 23 MHC class I alleles with that of 23 neutral microsatellite markers in adult great reed warblers (a passerine bird) in nine successive cohorts. Overall, the MHC alleles showed a significantly higher variation in allele frequencies between cohorts than the microsatellite alleles, using a multi-variate genetic analysis (AMOVA). The frequency of two specific MHC alleles, A3e (P = 0.046) and B4b (P = 0.0018), varied more between cohorts than expected from random, whereas none of the microsatellite alleles showed fluctuations exceeding the expectation from stochastic variation. These results imply that the variation in MHC allele frequencies between cohorts is not a result of demographic events, but rather an effect of selection favouring different MHC alleles in different years.},
  author       = {Westerdahl, Helena and Hansson, Bengt and Bensch, Staffan and Hasselquist, Dennis},
  issn         = {1420-9101},
  language     = {eng},
  number       = {3},
  pages        = {485--492},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Evolutionary Biology},
  title        = {Between-year variation of MHC allele frequencies in great reed warblers: selection or drift?},
  url          = {http://dx.doi.org/10.1111/j.1420-9101.2004.00711.x},
  volume       = {17},
  year         = {2004},
}