3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids infused into the peritoneal cavity cannot be found in plasma.
(2009) 12th Congress of the International-Society-for-Peritoneal-Dialysis In Peritoneal Dialysis International 29 Suppl 2. p.28-31- Abstract
- OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE and 3-DG in PD fluid can be found in plasma during treatment. DESIGN: Patients on PD were dialyzed with a conventional PD fluid containing 43 micromol/L 3,4-DGE and 281 micromol/L 3-DG. Parallel experiments were performed in rats and in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 micromol/L 3,4-DGE and 200... (More)
- OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE and 3-DG in PD fluid can be found in plasma during treatment. DESIGN: Patients on PD were dialyzed with a conventional PD fluid containing 43 micromol/L 3,4-DGE and 281 micromol/L 3-DG. Parallel experiments were performed in rats and in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 micromol/L 3,4-DGE and 200 micromol/L 3-DG. RESULTS: The 3,4-DGE concentration in the peritoneum declined at a much higher rate during the dwell than did the 3-DG concentration. However, 3,4-DGE was not detected in the plasma of patients or of rats during dialysis. The 3-DG concentration in plasma peaked shortly after infusion of fluid into the peritoneal cavity. The 3,4-DGE concentration during experimental incubation in plasma declined rapidly; the 3-DG concentration declined only 10% as rapidly (or less). CONCLUSION: During dialysis, 3,4-DGE could not be detected in plasma of either PD patients or rats, presumably because of its high reactivity. On the other hand, 3-DG may pass through the membrane and be detected in the blood. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1370642
- author
- Erixon, Martin LU ; Wieslander, Anders ; Lindén, Torbjörn ; Carlsson, Ola LU ; Jönsson, Jan Åke LU ; Simonsen, Ole LU and Kjellstrand, Per
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Peritoneal dialysis fluid, glucose degradation products, 3, 3-DG, 4-DGE, plasma, advanced glycation end-products
- in
- Peritoneal Dialysis International
- volume
- 29 Suppl 2
- pages
- 28 - 31
- publisher
- Multimed Inc.
- conference name
- 12th Congress of the International-Society-for-Peritoneal-Dialysis
- conference dates
- 2008-06-20 - 2008-06-24
- external identifiers
-
- wos:000263937100004
- pmid:19270226
- scopus:67449100957
- ISSN
- 1718-4304
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Nephrology (013230024), Analytical Chemistry (S/LTH) (011001004)
- id
- e95d6855-0201-4419-b9ab-5450a77a7854 (old id 1370642)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19270226?dopt=Abstract
- date added to LUP
- 2016-04-01 14:36:43
- date last changed
- 2022-01-30 03:59:18
@article{e95d6855-0201-4419-b9ab-5450a77a7854, abstract = {{OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE and 3-DG in PD fluid can be found in plasma during treatment. DESIGN: Patients on PD were dialyzed with a conventional PD fluid containing 43 micromol/L 3,4-DGE and 281 micromol/L 3-DG. Parallel experiments were performed in rats and in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 micromol/L 3,4-DGE and 200 micromol/L 3-DG. RESULTS: The 3,4-DGE concentration in the peritoneum declined at a much higher rate during the dwell than did the 3-DG concentration. However, 3,4-DGE was not detected in the plasma of patients or of rats during dialysis. The 3-DG concentration in plasma peaked shortly after infusion of fluid into the peritoneal cavity. The 3,4-DGE concentration during experimental incubation in plasma declined rapidly; the 3-DG concentration declined only 10% as rapidly (or less). CONCLUSION: During dialysis, 3,4-DGE could not be detected in plasma of either PD patients or rats, presumably because of its high reactivity. On the other hand, 3-DG may pass through the membrane and be detected in the blood.}}, author = {{Erixon, Martin and Wieslander, Anders and Lindén, Torbjörn and Carlsson, Ola and Jönsson, Jan Åke and Simonsen, Ole and Kjellstrand, Per}}, issn = {{1718-4304}}, keywords = {{Peritoneal dialysis fluid; glucose degradation products; 3; 3-DG; 4-DGE; plasma; advanced glycation end-products}}, language = {{eng}}, pages = {{28--31}}, publisher = {{Multimed Inc.}}, series = {{Peritoneal Dialysis International}}, title = {{3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids infused into the peritoneal cavity cannot be found in plasma.}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed/19270226?dopt=Abstract}}, volume = {{29 Suppl 2}}, year = {{2009}}, }