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Urinary transforming growth factor-1, collagen IV and the effect of insulin in children at diagnosis of diabetes mellitus

Holmquist, Peter LU and Torffvit, Ole LU (2009) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 43(2). p.142-147
Abstract
Objective. This study investigated whether metabolic derangement at diagnosis of diabetes mellitus affects the function of the basement membrane and the excretion of several components and whether insulin treatment can normalize this. It was designed to evaluate urinary excretion rates of transforming growth factor-1 (TGF-1), the carboxy-terminal domain of collagen IV (NC1) and albumin in children during the first 20 days of treatment after diagnosis of type 1 diabetes. Material and methods. Thirty-four newly diagnosed diabetic children between 4 and 16 years of age and 26 healthy children of matching age were studied with timed overnight urine collections. Urine was collected during the first 20 days of treatment. Results. Urinary... (More)
Objective. This study investigated whether metabolic derangement at diagnosis of diabetes mellitus affects the function of the basement membrane and the excretion of several components and whether insulin treatment can normalize this. It was designed to evaluate urinary excretion rates of transforming growth factor-1 (TGF-1), the carboxy-terminal domain of collagen IV (NC1) and albumin in children during the first 20 days of treatment after diagnosis of type 1 diabetes. Material and methods. Thirty-four newly diagnosed diabetic children between 4 and 16 years of age and 26 healthy children of matching age were studied with timed overnight urine collections. Urine was collected during the first 20 days of treatment. Results. Urinary excretion of albumin and TGF-1 in diabetic children were significantly increased at entry but normalized during 20 days of treatment with insulin compared with control children. In contrast, the non-significant high NC1 excretion at diagnosis did not change but became significantly increased after 20 days of insulin treatment. Overall, the kidney size was within normal limits and unaffected by treatment. The largest kidneys had less NC1 excretion (R= - 0.67, p0.05, n=13) and a lower glomerular filtration rate (R= - 0.77, p0.01, n=10) than the smallest kidneys. After 20 days of treatment TGF-1 excretion had decreased in children with kidney size 8.5 cm. Conclusion. Correction of the metabolic derangement with insulin decreased excretion of albumin and TGF-1, but had no effect on kidney size and urine NC1 excretion, presumably because the observation period was too short. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
growth factor-, transforming, type 1 diabetes, collagen IV, Albuminuria, children
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
43
issue
2
pages
142 - 147
publisher
Taylor & Francis
external identifiers
  • wos:000263717700009
  • scopus:61349167818
ISSN
0036-5599
DOI
10.1080/00365590802502111
language
English
LU publication?
yes
id
8c7c2b05-651d-46e9-b71c-dbed7ace277d (old id 1370874)
date added to LUP
2009-05-08 17:26:15
date last changed
2017-01-01 05:27:11
@article{8c7c2b05-651d-46e9-b71c-dbed7ace277d,
  abstract     = {Objective. This study investigated whether metabolic derangement at diagnosis of diabetes mellitus affects the function of the basement membrane and the excretion of several components and whether insulin treatment can normalize this. It was designed to evaluate urinary excretion rates of transforming growth factor-1 (TGF-1), the carboxy-terminal domain of collagen IV (NC1) and albumin in children during the first 20 days of treatment after diagnosis of type 1 diabetes. Material and methods. Thirty-four newly diagnosed diabetic children between 4 and 16 years of age and 26 healthy children of matching age were studied with timed overnight urine collections. Urine was collected during the first 20 days of treatment. Results. Urinary excretion of albumin and TGF-1 in diabetic children were significantly increased at entry but normalized during 20 days of treatment with insulin compared with control children. In contrast, the non-significant high NC1 excretion at diagnosis did not change but became significantly increased after 20 days of insulin treatment. Overall, the kidney size was within normal limits and unaffected by treatment. The largest kidneys had less NC1 excretion (R= - 0.67, p0.05, n=13) and a lower glomerular filtration rate (R= - 0.77, p0.01, n=10) than the smallest kidneys. After 20 days of treatment TGF-1 excretion had decreased in children with kidney size 8.5 cm. Conclusion. Correction of the metabolic derangement with insulin decreased excretion of albumin and TGF-1, but had no effect on kidney size and urine NC1 excretion, presumably because the observation period was too short.},
  author       = {Holmquist, Peter and Torffvit, Ole},
  issn         = {0036-5599},
  keyword      = {growth factor-,transforming,type 1 diabetes,collagen IV,Albuminuria,children},
  language     = {eng},
  number       = {2},
  pages        = {142--147},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Urinary transforming growth factor-1, collagen IV and the effect of insulin in children at diagnosis of diabetes mellitus},
  url          = {http://dx.doi.org/10.1080/00365590802502111},
  volume       = {43},
  year         = {2009},
}