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New susceptibility locus for coronary artery disease on chromosome 3q22.3

Erdmann, Jeanette; Grosshennig, Anika; Braund, Peter S.; Koenig, Inke R.; Hengstenberg, Christian; Hall, Alistair S.; Linsel-Nitschke, Patrick; Kathiresan, Sekar; Wright, Ben and Tregouet, David-Alexandre, et al. (2009) In Nature Genetics 41(3). p.280-282
Abstract
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
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publication status
published
subject
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Nature Genetics
volume
41
issue
3
pages
280 - 282
publisher
Nature Publishing Group
external identifiers
  • wos:000263640200006
  • scopus:61349177857
ISSN
1546-1718
DOI
10.1038/ng.307
language
English
LU publication?
yes
id
531b889d-0f2c-403e-809c-9fe2da54826c (old id 1370978)
date added to LUP
2009-05-08 15:38:23
date last changed
2017-11-19 04:00:49
@article{531b889d-0f2c-403e-809c-9fe2da54826c,
  abstract     = {We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).},
  author       = {Erdmann, Jeanette and Grosshennig, Anika and Braund, Peter S. and Koenig, Inke R. and Hengstenberg, Christian and Hall, Alistair S. and Linsel-Nitschke, Patrick and Kathiresan, Sekar and Wright, Ben and Tregouet, David-Alexandre and Cambien, Francois and Bruse, Petra and Aherrahrou, Zouhair and Wagner, Arnika K. and Stark, Klaus and Schwartz, Stephen M. and Salomaa, Veikko and Elosua, Roberto and Melander, Olle and Voight, Benjamin F. and O'Donnell, Christopher J. and Peltonen, Leena and Siscovick, David S. and Altshuler, David and Merlini, Piera Angelica and Peyvandi, Flora and Bernardinelli, Luisa and Ardissino, Diego and Schillert, Arne and Blankenberg, Stefan and Zeller, Tanja and Wild, Philipp and Schwarz, Daniel F. and Tiret, Laurence and Perret, Claire and Schreiber, Stefan and El Mokhtari, Nour Eddine and Schaefer, Arne and Maerz, Winfried and Renner, Wilfried and Bugert, Peter and Klueter, Harald and Schrezenmeir, Juergen and Rubin, Diana and Ball, Stephen G. and Balmforth, Anthony J. and Wichmann, H-Erich and Meitinger, Thomas and Fischer, Marcus and Meisinger, Christa and Baumert, Jens and Peters, Annette and Ouwehand, Willem H. and Deloukas, Panos and Thompson, John R. and Ziegler, Andreas and Samani, Nilesh J. and Schunkert, Heribert},
  issn         = {1546-1718},
  language     = {eng},
  number       = {3},
  pages        = {280--282},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {New susceptibility locus for coronary artery disease on chromosome 3q22.3},
  url          = {http://dx.doi.org/10.1038/ng.307},
  volume       = {41},
  year         = {2009},
}