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Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

Newton-Cheh, Christopher; Larson, Martin G.; Vasan, Ramachandran S.; Levy, Daniel; Bloch, Kenneth D.; Surti, Aarti; Guiducci, Candace; Kathiresan, Sekar; Benjamin, Emelia J. and Struck, Joachim, et al. (2009) In Nature Genetics 41(3). p.348-353
Abstract
We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P... (More)
We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension. (Less)
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Nature Genetics
volume
41
issue
3
pages
348 - 353
publisher
Nature Publishing Group
external identifiers
  • wos:000263640200017
  • scopus:61349089775
ISSN
1546-1718
DOI
10.1038/ng.328
language
English
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yes
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046cf35c-1829-4216-a3ac-acd8aadb229e (old id 1371038)
date added to LUP
2009-05-07 14:39:14
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2017-12-10 03:57:07
@article{046cf35c-1829-4216-a3ac-acd8aadb229e,
  abstract     = {We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.},
  author       = {Newton-Cheh, Christopher and Larson, Martin G. and Vasan, Ramachandran S. and Levy, Daniel and Bloch, Kenneth D. and Surti, Aarti and Guiducci, Candace and Kathiresan, Sekar and Benjamin, Emelia J. and Struck, Joachim and Morgenthaler, Nils G. and Bergmann, Andreas and Blankenberg, Stefan and Kee, Frank and Nilsson, Peter and Yin, Xiaoyan and Peltonen, Leena and Vartiainen, Erkki and Salomaa, Veikko and Hirschhorn, Joel N. and Melander, Olle and Wang, Thomas J.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {3},
  pages        = {348--353},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure},
  url          = {http://dx.doi.org/10.1038/ng.328},
  volume       = {41},
  year         = {2009},
}