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Cobalt-containing alloys and their ability to release cobalt and cause dermatitis

Julander, Anneli; Hindsén, Monica LU ; Skare, Lizbet and Liden, Carola (2009) In Contact Dermatitis 60(3). p.165-170
Abstract
Cobalt, nickel, and chromium are important skin sensitizers. However, knowledge about cobalt exposure and causes of cobalt sensitization is limited. To study release of cobalt, nickel, and chromium from some cobalt-containing hard metal alloys and to test reactivity to the materials in cobalt-sensitized patients. Discs suitable for patch testing were made of some hard metal alloys. Cobalt, nickel, and chromium release from the materials was determined by immersion in artificial sweat (2 min, 1 hr, 1 day, and 1 week). Patch test reactivity to the discs and to serial dilutions of cobalt and nickel was assessed in previously patch-tested dermatitis patients (19 cobalt positive and 18 cobalt-negative controls). All discs released cobalt,... (More)
Cobalt, nickel, and chromium are important skin sensitizers. However, knowledge about cobalt exposure and causes of cobalt sensitization is limited. To study release of cobalt, nickel, and chromium from some cobalt-containing hard metal alloys and to test reactivity to the materials in cobalt-sensitized patients. Discs suitable for patch testing were made of some hard metal alloys. Cobalt, nickel, and chromium release from the materials was determined by immersion in artificial sweat (2 min, 1 hr, 1 day, and 1 week). Patch test reactivity to the discs and to serial dilutions of cobalt and nickel was assessed in previously patch-tested dermatitis patients (19 cobalt positive and 18 cobalt-negative controls). All discs released cobalt, nickel, and chromium. Some discs released large amounts of cobalt (highest concentration: 290 mu g/cm(2)/week). Seven discs elicited three or more positive test reactions. The concentration of released cobalt was high enough to elicit allergic contact dermatitis in cobalt-sensitized patients. As the materials in the discs are used in wear parts of hard metal tools, individuals with contact allergy to cobalt may develop hand eczema when handling such materials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acid wipe sampling, allergic contact dermatitis, chemical analysis, chromium, cobalt, nickel, patch tests, occupational exposure
in
Contact Dermatitis
volume
60
issue
3
pages
165 - 170
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000263679600008
  • scopus:61349123212
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2008.01497.x
language
English
LU publication?
yes
id
d990fdb4-573c-4910-8883-b9d0c38f0e3c (old id 1371928)
date added to LUP
2009-05-08 12:28:35
date last changed
2017-05-21 03:43:29
@article{d990fdb4-573c-4910-8883-b9d0c38f0e3c,
  abstract     = {Cobalt, nickel, and chromium are important skin sensitizers. However, knowledge about cobalt exposure and causes of cobalt sensitization is limited. To study release of cobalt, nickel, and chromium from some cobalt-containing hard metal alloys and to test reactivity to the materials in cobalt-sensitized patients. Discs suitable for patch testing were made of some hard metal alloys. Cobalt, nickel, and chromium release from the materials was determined by immersion in artificial sweat (2 min, 1 hr, 1 day, and 1 week). Patch test reactivity to the discs and to serial dilutions of cobalt and nickel was assessed in previously patch-tested dermatitis patients (19 cobalt positive and 18 cobalt-negative controls). All discs released cobalt, nickel, and chromium. Some discs released large amounts of cobalt (highest concentration: 290 mu g/cm(2)/week). Seven discs elicited three or more positive test reactions. The concentration of released cobalt was high enough to elicit allergic contact dermatitis in cobalt-sensitized patients. As the materials in the discs are used in wear parts of hard metal tools, individuals with contact allergy to cobalt may develop hand eczema when handling such materials.},
  author       = {Julander, Anneli and Hindsén, Monica and Skare, Lizbet and Liden, Carola},
  issn         = {0105-1873},
  keyword      = {acid wipe sampling,allergic contact dermatitis,chemical analysis,chromium,cobalt,nickel,patch tests,occupational exposure},
  language     = {eng},
  number       = {3},
  pages        = {165--170},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Cobalt-containing alloys and their ability to release cobalt and cause dermatitis},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2008.01497.x},
  volume       = {60},
  year         = {2009},
}