Advanced

Androgen receptor gene polymorphism and sex hormones in elderly men: the Tromso study

Skjaerpe, Paal Andre; Giwercman, Yvonne LU ; Giwercman, Aleksander LU and Svartberg, Johan (2009) In Asian Journal of Andrology 11(2). p.222-228
Abstract
The aim of this study was to examine whether CAG/GGN repeats are significant modulators of serum concentrations of total and free testosterone (T) as well as of luteinizing hormone (LH) in elderly men. Sixty-nine 60- to 80-year-old men with subnormal T levels (<= 11.0 nmol L-1) and 104 men with normal T levels taking part in a nested case-control study were used for these analyses. Sex hormones were measured and free T was calculated. The CAG and GGN polymorphisms in the androgen receptor gene were determined by polymerase chain reaction and subsequent direct sequencing. There were no differences in the CAG and GGN repeat lengths between the groups. In cross-sectional analyses of the whole cohort, total and free T were positively... (More)
The aim of this study was to examine whether CAG/GGN repeats are significant modulators of serum concentrations of total and free testosterone (T) as well as of luteinizing hormone (LH) in elderly men. Sixty-nine 60- to 80-year-old men with subnormal T levels (<= 11.0 nmol L-1) and 104 men with normal T levels taking part in a nested case-control study were used for these analyses. Sex hormones were measured and free T was calculated. The CAG and GGN polymorphisms in the androgen receptor gene were determined by polymerase chain reaction and subsequent direct sequencing. There were no differences in the CAG and GGN repeat lengths between the groups. In cross-sectional analyses of the whole cohort, total and free T were positively associated with CAG length (all P < 0.05) before, but not after, waist circumference or body mass index was added to the model. CAG repeat lengths were weakly, but not independently, associated with total and free T. These findings indicate that when clinically evaluating T and LH levels in elderly men, the CAG and GGN repeat lengths do not need to be taken into consideration. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
androgen receptor gene polymorphism, testosterone, luteinizing hormone
in
Asian Journal of Andrology
volume
11
issue
2
pages
222 - 228
publisher
Nature Publishing Group
external identifiers
  • wos:000263769000012
  • pmid:19137002
  • scopus:69249214281
ISSN
1008-682X
DOI
10.1038/aja.2008.7
language
English
LU publication?
yes
id
5a02f144-128a-4313-9bd8-8269ea887657 (old id 1371988)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19137002?dopt=Abstract
date added to LUP
2009-05-07 13:12:40
date last changed
2017-01-01 05:06:29
@article{5a02f144-128a-4313-9bd8-8269ea887657,
  abstract     = {The aim of this study was to examine whether CAG/GGN repeats are significant modulators of serum concentrations of total and free testosterone (T) as well as of luteinizing hormone (LH) in elderly men. Sixty-nine 60- to 80-year-old men with subnormal T levels (&lt;= 11.0 nmol L-1) and 104 men with normal T levels taking part in a nested case-control study were used for these analyses. Sex hormones were measured and free T was calculated. The CAG and GGN polymorphisms in the androgen receptor gene were determined by polymerase chain reaction and subsequent direct sequencing. There were no differences in the CAG and GGN repeat lengths between the groups. In cross-sectional analyses of the whole cohort, total and free T were positively associated with CAG length (all P &lt; 0.05) before, but not after, waist circumference or body mass index was added to the model. CAG repeat lengths were weakly, but not independently, associated with total and free T. These findings indicate that when clinically evaluating T and LH levels in elderly men, the CAG and GGN repeat lengths do not need to be taken into consideration.},
  author       = {Skjaerpe, Paal Andre and Giwercman, Yvonne and Giwercman, Aleksander and Svartberg, Johan},
  issn         = {1008-682X},
  keyword      = {androgen receptor gene polymorphism,testosterone,luteinizing hormone},
  language     = {eng},
  number       = {2},
  pages        = {222--228},
  publisher    = {Nature Publishing Group},
  series       = {Asian Journal of Andrology},
  title        = {Androgen receptor gene polymorphism and sex hormones in elderly men: the Tromso study},
  url          = {http://dx.doi.org/10.1038/aja.2008.7},
  volume       = {11},
  year         = {2009},
}