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Mechanisms and significance of lipoprotein(a) in hepatocellular carcinoma

Jiang, Jing-Ting; Wu, Chang-Ping; Xu, Ning LU and Zhang, Xue-Guang (2009) In Hepatobiliary & Pancreatic Diseases International 8(1). p.25-28
Abstract
BACKGROUND: The liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma is one of the most common fatal malignant tumors in China and in other Southeast Asian countries. It has been demonstrated that plasma lipid profiles are changed in liver cancer. DATA SOURCES: A MEDLINE database search was performed to identify relevant articles using the keywords "hepatocellular carcinoma" and "lipoprotein(a)". The search was conducted and research articles were reviewed from 1960 to 2008. RESULTS: Production and homeostasis of lipids, apolipoproteins and lipoproteins depend on the integrity of hepatocellular functions, which ensures normal lipid and lipoprotein metabolism in... (More)
BACKGROUND: The liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma is one of the most common fatal malignant tumors in China and in other Southeast Asian countries. It has been demonstrated that plasma lipid profiles are changed in liver cancer. DATA SOURCES: A MEDLINE database search was performed to identify relevant articles using the keywords "hepatocellular carcinoma" and "lipoprotein(a)". The search was conducted and research articles were reviewed from 1960 to 2008. RESULTS: Production and homeostasis of lipids, apolipoproteins and lipoproteins depend on the integrity of hepatocellular functions, which ensures normal lipid and lipoprotein metabolism in vivo. When hepatocellular injury or liver cancer occurs these processes can be impaired. It has been suggested that plasma levels of apolipoprotein(a) (apo(a)) and/or lipoprotein (a) (Lp(a)) may be considered as sensitive markers of hepatic impairment. CONCLUSIONS: Plasma levels of apo(a) and Lp(a) display significant correlations with hepatic status. Most studies demonstrated that the plasma levels of apo(a) and Lp(a) can be considered as an additional clinical index of liver function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hepatocellular carcinoma, metabolism, lipoprotein(a), apolipoprotein(a)
in
Hepatobiliary & Pancreatic Diseases International
volume
8
issue
1
pages
25 - 28
publisher
Zhejiang Univ Sch Medicine
external identifiers
  • wos:000263488600004
  • scopus:60549094208
ISSN
1499-3872
language
English
LU publication?
yes
id
2ade8731-4ac7-4dea-8244-cb4aaa7cc264 (old id 1372201)
date added to LUP
2009-05-08 17:39:41
date last changed
2017-01-01 05:51:26
@article{2ade8731-4ac7-4dea-8244-cb4aaa7cc264,
  abstract     = {BACKGROUND: The liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma is one of the most common fatal malignant tumors in China and in other Southeast Asian countries. It has been demonstrated that plasma lipid profiles are changed in liver cancer. DATA SOURCES: A MEDLINE database search was performed to identify relevant articles using the keywords "hepatocellular carcinoma" and "lipoprotein(a)". The search was conducted and research articles were reviewed from 1960 to 2008. RESULTS: Production and homeostasis of lipids, apolipoproteins and lipoproteins depend on the integrity of hepatocellular functions, which ensures normal lipid and lipoprotein metabolism in vivo. When hepatocellular injury or liver cancer occurs these processes can be impaired. It has been suggested that plasma levels of apolipoprotein(a) (apo(a)) and/or lipoprotein (a) (Lp(a)) may be considered as sensitive markers of hepatic impairment. CONCLUSIONS: Plasma levels of apo(a) and Lp(a) display significant correlations with hepatic status. Most studies demonstrated that the plasma levels of apo(a) and Lp(a) can be considered as an additional clinical index of liver function.},
  author       = {Jiang, Jing-Ting and Wu, Chang-Ping and Xu, Ning and Zhang, Xue-Guang},
  issn         = {1499-3872},
  keyword      = {hepatocellular carcinoma,metabolism,lipoprotein(a),apolipoprotein(a)},
  language     = {eng},
  number       = {1},
  pages        = {25--28},
  publisher    = {Zhejiang Univ Sch Medicine},
  series       = {Hepatobiliary & Pancreatic Diseases International},
  title        = {Mechanisms and significance of lipoprotein(a) in hepatocellular carcinoma},
  volume       = {8},
  year         = {2009},
}