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Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index

Huth, Cornelia; Illig, Thomas; Herder, Christian; Gieger, Christian; Grallert, Harald; Vollmert, Caren; Rathmann, Wolfgang; Hamid, Yasmin H.; Pedersen, Oluf and Hansen, Torben, et al. (2009) In Annals of Medicine 41(2). p.128-138
Abstract
Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and... (More)
Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174GC and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174GC polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects. (Less)
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keywords
meta-analysis, molecular epidemiology, single nucleotide polymorphism, intermediate phenotype, interleukin-6, inflammation mediators, genes, diabetes mellitus type 2, Blood glucose, body mass index
in
Annals of Medicine
volume
41
issue
2
pages
128 - 138
publisher
Informa Healthcare
external identifiers
  • wos:000263560900005
  • scopus:61349133510
ISSN
1365-2060
DOI
10.1080/07853890802337037
language
English
LU publication?
yes
id
84a8aa59-92c0-4560-878f-f5cb36eab6f0 (old id 1372595)
date added to LUP
2009-05-08 15:08:11
date last changed
2017-11-19 03:36:20
@article{84a8aa59-92c0-4560-878f-f5cb36eab6f0,
  abstract     = {Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174GC and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174GC polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.},
  author       = {Huth, Cornelia and Illig, Thomas and Herder, Christian and Gieger, Christian and Grallert, Harald and Vollmert, Caren and Rathmann, Wolfgang and Hamid, Yasmin H. and Pedersen, Oluf and Hansen, Torben and Thorand, Barbara and Meisinger, Christa and Doering, Angela and Klopp, Norman and Gohlke, Henning and Lieb, Wolfgang and Hengstenberg, Christian and Lyssenko, Valeriya and Groop, Leif and Ireland, Helen and Stephens, Jeffrey W. and Asterholm, Ingrid Wernstedt and Jansson, John-Olov and Boeing, Heiner and Moehlig, Matthias and Stringham, Heather M. and Boehnke, Michael and Tuomilehto, Jaakko and Fernandez-Real, Jose-Manuel and Lopez-Bermejo, Abel and Gallart, Luis and Vendrell, Joan and Humphries, Steve E. and Kronenberg, Florian and Wichmann, H. -Erich and Heid, Iris M.},
  issn         = {1365-2060},
  keyword      = {meta-analysis,molecular epidemiology,single nucleotide polymorphism,intermediate phenotype,interleukin-6,inflammation mediators,genes,diabetes mellitus type 2,Blood glucose,body mass index},
  language     = {eng},
  number       = {2},
  pages        = {128--138},
  publisher    = {Informa Healthcare},
  series       = {Annals of Medicine},
  title        = {Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index},
  url          = {http://dx.doi.org/10.1080/07853890802337037},
  volume       = {41},
  year         = {2009},
}