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Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population

Tai, E. Shyong; Sim, Xue Ling; Ong, Twee Hee; Wong, Tien Yin; Saw, Seang Mei; Aung, Tin; Kathiresan, Sekar; Orho-Melander, Marju LU ; Ordovas, Jose M. and Tan, Jonathan T., et al. (2009) In Journal of Lipid Research 50(3). p.514-520
Abstract
We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on... (More)
We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also to understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.-Tai, E. S., X. L. Sim, T. H. Ong, T. Y. Wong, S. M. Saw, T. Aung, S. Kathiresan, M. Orho-Melander, J. M. Ordovas, J. T. Tan, and M. Seielstad. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J. Lipid Res. 2009. 50: 514-520. (Less)
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published
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keywords
genetics, ethnic group, coronary heart disease
in
Journal of Lipid Research
volume
50
issue
3
pages
514 - 520
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • wos:000263317600016
  • scopus:64349100189
ISSN
1539-7262
DOI
10.1194/jlr.M800456-JLR200
language
English
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yes
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eb80ab22-682f-4c4f-9dcb-e7346f9032b9 (old id 1374937)
date added to LUP
2009-05-08 16:09:14
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2017-11-12 03:20:58
@article{eb80ab22-682f-4c4f-9dcb-e7346f9032b9,
  abstract     = {We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values &lt;0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also to understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.-Tai, E. S., X. L. Sim, T. H. Ong, T. Y. Wong, S. M. Saw, T. Aung, S. Kathiresan, M. Orho-Melander, J. M. Ordovas, J. T. Tan, and M. Seielstad. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J. Lipid Res. 2009. 50: 514-520.},
  author       = {Tai, E. Shyong and Sim, Xue Ling and Ong, Twee Hee and Wong, Tien Yin and Saw, Seang Mei and Aung, Tin and Kathiresan, Sekar and Orho-Melander, Marju and Ordovas, Jose M. and Tan, Jonathan T. and Seielstad, Mark},
  issn         = {1539-7262},
  keyword      = {genetics,ethnic group,coronary heart disease},
  language     = {eng},
  number       = {3},
  pages        = {514--520},
  publisher    = {American Society for Biochemistry and Molecular Biology},
  series       = {Journal of Lipid Research},
  title        = {Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population},
  url          = {http://dx.doi.org/10.1194/jlr.M800456-JLR200},
  volume       = {50},
  year         = {2009},
}