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Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients

Werner, Marten; Almer, Sven; Prytz, Hanne LU ; Lindgren, Stefan LU ; Wallerstedt, Sven; Bjoersson, Einar; Bergquist, Annika; Sandberg-Gertzen, Hanna; Hultcrantz, Rolf and Sangfelt, Per, et al. (2009) In Journal of Hepatology 50(2). p.388-393
Abstract
Background/Aims: Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients. Methods: Four hundred and seventy-three patients with AIH were matched to the Swedish national cancer register as well as to the death cause register. Results: We found an overall higher risk of malignancies in the cohort of A I H patients from the date of diagnosis with a SIR of 1.51 (95% CI 1.10-2.03). SIR in the subpopulation of well defined catchment areas and... (More)
Background/Aims: Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients. Methods: Four hundred and seventy-three patients with AIH were matched to the Swedish national cancer register as well as to the death cause register. Results: We found an overall higher risk of malignancies in the cohort of A I H patients from the date of diagnosis with a SIR of 1.51 (95% CI 1.10-2.03). SIR in the subpopulation of well defined catchment areas and complete case finding was 23.28 (95% CI 7.5-54.34) for HCC. Lymphomas were found a SIR of 13.09 (95% CI 4.22-30.56). Conclusions: There was an overall increased risk of malignancies in a cohort of AIH patients, which manly was caused by hepatobiliary cancers. However, the true risk of HCC in an AIH cirrhotic cohort has yet to be investigated. A significantly higher risk of lymphomas was also found, but no clear cut association to the use of immune modulators. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. (Less)
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publication status
published
subject
keywords
Malignancies, Lymphoma, Autoimmune hepatitis, Hepatocellular carcinoma
in
Journal of Hepatology
volume
50
issue
2
pages
388 - 393
publisher
Elsevier
external identifiers
  • wos:000263309000021
  • scopus:58149311072
ISSN
0168-8278
DOI
10.1016/j.jhep.2008.08.022
language
English
LU publication?
yes
id
ee544a2f-f522-4398-b6c3-a37b3aebc40e (old id 1374950)
date added to LUP
2009-05-08 14:22:41
date last changed
2017-12-10 03:49:29
@article{ee544a2f-f522-4398-b6c3-a37b3aebc40e,
  abstract     = {Background/Aims: Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients. Methods: Four hundred and seventy-three patients with AIH were matched to the Swedish national cancer register as well as to the death cause register. Results: We found an overall higher risk of malignancies in the cohort of A I H patients from the date of diagnosis with a SIR of 1.51 (95% CI 1.10-2.03). SIR in the subpopulation of well defined catchment areas and complete case finding was 23.28 (95% CI 7.5-54.34) for HCC. Lymphomas were found a SIR of 13.09 (95% CI 4.22-30.56). Conclusions: There was an overall increased risk of malignancies in a cohort of AIH patients, which manly was caused by hepatobiliary cancers. However, the true risk of HCC in an AIH cirrhotic cohort has yet to be investigated. A significantly higher risk of lymphomas was also found, but no clear cut association to the use of immune modulators. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.},
  author       = {Werner, Marten and Almer, Sven and Prytz, Hanne and Lindgren, Stefan and Wallerstedt, Sven and Bjoersson, Einar and Bergquist, Annika and Sandberg-Gertzen, Hanna and Hultcrantz, Rolf and Sangfelt, Per and Weiland, Ola and Danielsson, Ake},
  issn         = {0168-8278},
  keyword      = {Malignancies,Lymphoma,Autoimmune hepatitis,Hepatocellular carcinoma},
  language     = {eng},
  number       = {2},
  pages        = {388--393},
  publisher    = {Elsevier},
  series       = {Journal of Hepatology},
  title        = {Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients},
  url          = {http://dx.doi.org/10.1016/j.jhep.2008.08.022},
  volume       = {50},
  year         = {2009},
}