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Microwaves From UMTS/GSM Mobile Phones Induce Long-Lasting Inhibition of 53BP1/gamma-H2AX DNA Repair Foci in Human Lymphocytes

Belyaev, Igor Y.; Markova, Eva; Hillert, Lena; Malmgren, Lars LU and Persson, Bertil R. R. (2009) In Bioelectromagnetics 30(2). p.129-141
Abstract
We have recently described frequency-dependent effects of mobile phone microwaves (MWs) of global system for mobile communication (GSM) on human lymphocytes from persons reporting hypersensitivity to electromagnetic fields and healthy persons. Contrary to GSM, universal global telecommunications system (UMTS) mobile phones emit wide-band MW signals. Hypothetically, UMTS MWs may result in higher biological effects compared to GSM signal because of eventual "effective" frequencies within the wideband. Here, we report for the first time that UMTS MWs affect chromatin and inhibit formation of DNA double-strand breaks co-localizing 53BP1/gamma-H2AX DNA repair foci in human lymphocytes from hypersensitive and healthy persons and confirm that... (More)
We have recently described frequency-dependent effects of mobile phone microwaves (MWs) of global system for mobile communication (GSM) on human lymphocytes from persons reporting hypersensitivity to electromagnetic fields and healthy persons. Contrary to GSM, universal global telecommunications system (UMTS) mobile phones emit wide-band MW signals. Hypothetically, UMTS MWs may result in higher biological effects compared to GSM signal because of eventual "effective" frequencies within the wideband. Here, we report for the first time that UMTS MWs affect chromatin and inhibit formation of DNA double-strand breaks co-localizing 53BP1/gamma-H2AX DNA repair foci in human lymphocytes from hypersensitive and healthy persons and confirm that effects of GSM MWs depend oil carrier frequency. Remarkably, the effects of MWs on 53BP1/gamma-H2AX foci persisted up to 72 h following exposure of cells, even longer than the stress response following heat shock. The data are in line with the hypothesis that the type of signal, UMTS MWs, may have higher biological efficiency and possibly larger health risk effects compared to GSM radiation emissions. No significant differences in effects between groups of healthy and hypersensitive subjects were observed, except for the effects of UNITS MWs and GSM-915 MHz MWs on the formation of the DNA repair foci, which were different for hypersensitive (P < 0.02[53BP1)//0.01[gamma-H2AX]) but not for control subjects (P > 0.05). The non-parametric statistics used here did not indicate specificity of the differences revealed between the effects of GSM and UMTS MWs oil cells from hypersensitive subjects and more data are needed to study the nature of these differences, Bioelectromagnetics 30: 129-141, 2009. (C) 2008 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
apoptosis, stress response, nucleoid, chromatin, DNA double-strand breaks, DNA repair foci co-localization
in
Bioelectromagnetics
volume
30
issue
2
pages
129 - 141
publisher
John Wiley & Sons
external identifiers
  • wos:000263303900006
  • scopus:63149182158
ISSN
0197-8462
DOI
10.1002/bem.20445
language
English
LU publication?
yes
id
522e485f-72ae-4a36-b033-170014a48498 (old id 1375085)
date added to LUP
2009-05-08 15:28:54
date last changed
2017-07-30 03:44:14
@article{522e485f-72ae-4a36-b033-170014a48498,
  abstract     = {We have recently described frequency-dependent effects of mobile phone microwaves (MWs) of global system for mobile communication (GSM) on human lymphocytes from persons reporting hypersensitivity to electromagnetic fields and healthy persons. Contrary to GSM, universal global telecommunications system (UMTS) mobile phones emit wide-band MW signals. Hypothetically, UMTS MWs may result in higher biological effects compared to GSM signal because of eventual "effective" frequencies within the wideband. Here, we report for the first time that UMTS MWs affect chromatin and inhibit formation of DNA double-strand breaks co-localizing 53BP1/gamma-H2AX DNA repair foci in human lymphocytes from hypersensitive and healthy persons and confirm that effects of GSM MWs depend oil carrier frequency. Remarkably, the effects of MWs on 53BP1/gamma-H2AX foci persisted up to 72 h following exposure of cells, even longer than the stress response following heat shock. The data are in line with the hypothesis that the type of signal, UMTS MWs, may have higher biological efficiency and possibly larger health risk effects compared to GSM radiation emissions. No significant differences in effects between groups of healthy and hypersensitive subjects were observed, except for the effects of UNITS MWs and GSM-915 MHz MWs on the formation of the DNA repair foci, which were different for hypersensitive (P &lt; 0.02[53BP1)//0.01[gamma-H2AX]) but not for control subjects (P &gt; 0.05). The non-parametric statistics used here did not indicate specificity of the differences revealed between the effects of GSM and UMTS MWs oil cells from hypersensitive subjects and more data are needed to study the nature of these differences, Bioelectromagnetics 30: 129-141, 2009. (C) 2008 Wiley-Liss, Inc.},
  author       = {Belyaev, Igor Y. and Markova, Eva and Hillert, Lena and Malmgren, Lars and Persson, Bertil R. R.},
  issn         = {0197-8462},
  keyword      = {apoptosis,stress response,nucleoid,chromatin,DNA double-strand breaks,DNA repair foci co-localization},
  language     = {eng},
  number       = {2},
  pages        = {129--141},
  publisher    = {John Wiley & Sons},
  series       = {Bioelectromagnetics},
  title        = {Microwaves From UMTS/GSM Mobile Phones Induce Long-Lasting Inhibition of 53BP1/gamma-H2AX DNA Repair Foci in Human Lymphocytes},
  url          = {http://dx.doi.org/10.1002/bem.20445},
  volume       = {30},
  year         = {2009},
}