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Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitis

Andersson, Morgan LU ; Greiff, Lennart LU and Wollmer, Per LU (2008) In Acta Oto-Laryngologica 128(6). p.666-669
Abstract
Conclusions. Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis. Objective. To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model. Patients and methods. Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried... (More)
Conclusions. Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis. Objective. To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model. Patients and methods. Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried out and symptoms of allergic rhinitis were scored. Furthermore, nasal lavages were performed and levels of the plasma protein alpha(2)-macroglobulin were measured as an index of exudative inflammation. Results. The allergen challenges produced significant increases in nasal symptoms (p = 0.007) and in nasal lavage fluid levels of alpha(2)-macroglobulin (p = 0.008). The challenge-induced symptoms as well as the plasma exudation were attenuated by treatment with the microemulsion (p = 0.016 and 0.012, respectively, compared with placebo). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
rhinitis, plasma exudation, Airway, inflammation
in
Acta Oto-Laryngologica
volume
128
issue
6
pages
666 - 669
publisher
Taylor & Francis
external identifiers
  • wos:000256752900011
  • scopus:45849086933
ISSN
1651-2251
DOI
10.1080/00016480701642197
language
English
LU publication?
yes
id
05c5a5d0-00cf-4c07-b1f0-f7fb75e6260e (old id 1375628)
date added to LUP
2009-05-08 15:35:09
date last changed
2017-10-22 04:04:25
@article{05c5a5d0-00cf-4c07-b1f0-f7fb75e6260e,
  abstract     = {Conclusions. Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis. Objective. To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model. Patients and methods. Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried out and symptoms of allergic rhinitis were scored. Furthermore, nasal lavages were performed and levels of the plasma protein alpha(2)-macroglobulin were measured as an index of exudative inflammation. Results. The allergen challenges produced significant increases in nasal symptoms (p = 0.007) and in nasal lavage fluid levels of alpha(2)-macroglobulin (p = 0.008). The challenge-induced symptoms as well as the plasma exudation were attenuated by treatment with the microemulsion (p = 0.016 and 0.012, respectively, compared with placebo).},
  author       = {Andersson, Morgan and Greiff, Lennart and Wollmer, Per},
  issn         = {1651-2251},
  keyword      = {rhinitis,plasma exudation,Airway,inflammation},
  language     = {eng},
  number       = {6},
  pages        = {666--669},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitis},
  url          = {http://dx.doi.org/10.1080/00016480701642197},
  volume       = {128},
  year         = {2008},
}