Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitis
(2008) In Acta Oto-Laryngologica 128(6). p.666-669- Abstract
- Conclusions. Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis. Objective. To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model. Patients and methods. Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried... (More)
- Conclusions. Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis. Objective. To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model. Patients and methods. Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried out and symptoms of allergic rhinitis were scored. Furthermore, nasal lavages were performed and levels of the plasma protein alpha(2)-macroglobulin were measured as an index of exudative inflammation. Results. The allergen challenges produced significant increases in nasal symptoms (p = 0.007) and in nasal lavage fluid levels of alpha(2)-macroglobulin (p = 0.008). The challenge-induced symptoms as well as the plasma exudation were attenuated by treatment with the microemulsion (p = 0.016 and 0.012, respectively, compared with placebo). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1375628
- author
- Andersson, Morgan LU ; Greiff, Lennart LU and Wollmer, Per LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- rhinitis, plasma exudation, Airway, inflammation
- in
- Acta Oto-Laryngologica
- volume
- 128
- issue
- 6
- pages
- 666 - 669
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000256752900011
- scopus:45849086933
- pmid:18568502
- ISSN
- 1651-2251
- DOI
- 10.1080/00016480701642197
- language
- English
- LU publication?
- yes
- id
- 05c5a5d0-00cf-4c07-b1f0-f7fb75e6260e (old id 1375628)
- date added to LUP
- 2016-04-01 13:17:26
- date last changed
- 2023-09-02 21:46:05
@article{05c5a5d0-00cf-4c07-b1f0-f7fb75e6260e,
abstract = {{Conclusions. Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis. Objective. To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model. Patients and methods. Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried out and symptoms of allergic rhinitis were scored. Furthermore, nasal lavages were performed and levels of the plasma protein alpha(2)-macroglobulin were measured as an index of exudative inflammation. Results. The allergen challenges produced significant increases in nasal symptoms (p = 0.007) and in nasal lavage fluid levels of alpha(2)-macroglobulin (p = 0.008). The challenge-induced symptoms as well as the plasma exudation were attenuated by treatment with the microemulsion (p = 0.016 and 0.012, respectively, compared with placebo).}},
author = {{Andersson, Morgan and Greiff, Lennart and Wollmer, Per}},
issn = {{1651-2251}},
keywords = {{rhinitis; plasma exudation; Airway; inflammation}},
language = {{eng}},
number = {{6}},
pages = {{666--669}},
publisher = {{Taylor & Francis}},
series = {{Acta Oto-Laryngologica}},
title = {{Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitis}},
url = {{http://dx.doi.org/10.1080/00016480701642197}},
doi = {{10.1080/00016480701642197}},
volume = {{128}},
year = {{2008}},
}