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Prospective Study of Chemotherapy in Combination with Cytokine-induced Killer Cells in Patients Suffering from Advanced Non-small Cell Lung Cancer

Wu, Changping; Jiang, Jingting; Shi, Liangrong and Xu, Ning LU (2008) In Anticancer Research 28(6B). p.3997-4002
Abstract
The present study evaluated the clinical efficacy of chemotherapy in combination with cytokine-induced killer (CIK) biotherapy compared to the chemotherapy alone. Fifty-nine advanced non-small cell lung cancer (NSCLC) patients were randomly divided into two groups, group A (chemotherapy, alone, including docetaxel 75 mg/m(2), day 1; cisplatin, 25 mg/m(2), days 1-4, tri-weekly) and group B (chemotherapy plus CIK cell transfusion). Autologous ClK cells were induced from the patients' peripheral mononuclear cells in vitro and separated by cytometry and then transfused back the patients. The host cellular immune function, clinical curative effects and quality of life (QOL) were examined and were compared between the two groups. The host immune... (More)
The present study evaluated the clinical efficacy of chemotherapy in combination with cytokine-induced killer (CIK) biotherapy compared to the chemotherapy alone. Fifty-nine advanced non-small cell lung cancer (NSCLC) patients were randomly divided into two groups, group A (chemotherapy, alone, including docetaxel 75 mg/m(2), day 1; cisplatin, 25 mg/m(2), days 1-4, tri-weekly) and group B (chemotherapy plus CIK cell transfusion). Autologous ClK cells were induced from the patients' peripheral mononuclear cells in vitro and separated by cytometry and then transfused back the patients. The host cellular immune function, clinical curative effects and quality of life (QOL) were examined and were compared between the two groups. The host immune function was enhanced and QOL was improved in the patients treated by chemotherapy, plus CIK biotherapy compared to the patients treated by chemotherapy alone. The overall response rate (ORR) was 43.3 % and 44.8% in groups A and B, respectively. The disease control rate (DCR) was higher in group B than in group A (89.7% vs. 65.5%, p=0.030). The time to progression was 4.67 months (95% CI 3.98-6.02 months) in group A and 6.65 months (95% CI 4.70-7.30 months) in group B and the median survival time was 11.0 months (95% CI 7.88-14.1 months) in group A and 15.0 months (95% CI 11.04-18.96 months) in group B. Compared to patients in group A, the patients in group B had significantly longer progression-free survival (p=0.042) and overall survival (p=0.029). No severe side-effects occurred in the ClK cell transfusion patients. It was concluded that chemotherapy plus CIK cells has potential benefits compared to chemotherapy alone in patients suffering from advanced NSCLC and autologous CIK cell transfusion has no obvious side-effects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunotherapy, Non-small cell lung cancer, cytokine-induced killer cells
in
Anticancer Research
volume
28
issue
6B
pages
3997 - 4002
publisher
International Institute of Cancer Research
external identifiers
  • wos:000262049500027
  • scopus:58149165343
ISSN
1791-7530
language
English
LU publication?
yes
id
ccbc45a2-9613-41a0-97a8-bb85b45bd222 (old id 1376126)
date added to LUP
2009-05-08 16:14:28
date last changed
2017-09-03 03:52:20
@article{ccbc45a2-9613-41a0-97a8-bb85b45bd222,
  abstract     = {The present study evaluated the clinical efficacy of chemotherapy in combination with cytokine-induced killer (CIK) biotherapy compared to the chemotherapy alone. Fifty-nine advanced non-small cell lung cancer (NSCLC) patients were randomly divided into two groups, group A (chemotherapy, alone, including docetaxel 75 mg/m(2), day 1; cisplatin, 25 mg/m(2), days 1-4, tri-weekly) and group B (chemotherapy plus CIK cell transfusion). Autologous ClK cells were induced from the patients' peripheral mononuclear cells in vitro and separated by cytometry and then transfused back the patients. The host cellular immune function, clinical curative effects and quality of life (QOL) were examined and were compared between the two groups. The host immune function was enhanced and QOL was improved in the patients treated by chemotherapy, plus CIK biotherapy compared to the patients treated by chemotherapy alone. The overall response rate (ORR) was 43.3 % and 44.8% in groups A and B, respectively. The disease control rate (DCR) was higher in group B than in group A (89.7% vs. 65.5%, p=0.030). The time to progression was 4.67 months (95% CI 3.98-6.02 months) in group A and 6.65 months (95% CI 4.70-7.30 months) in group B and the median survival time was 11.0 months (95% CI 7.88-14.1 months) in group A and 15.0 months (95% CI 11.04-18.96 months) in group B. Compared to patients in group A, the patients in group B had significantly longer progression-free survival (p=0.042) and overall survival (p=0.029). No severe side-effects occurred in the ClK cell transfusion patients. It was concluded that chemotherapy plus CIK cells has potential benefits compared to chemotherapy alone in patients suffering from advanced NSCLC and autologous CIK cell transfusion has no obvious side-effects.},
  author       = {Wu, Changping and Jiang, Jingting and Shi, Liangrong and Xu, Ning},
  issn         = {1791-7530},
  keyword      = {immunotherapy,Non-small cell lung cancer,cytokine-induced killer cells},
  language     = {eng},
  number       = {6B},
  pages        = {3997--4002},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Prospective Study of Chemotherapy in Combination with Cytokine-induced Killer Cells in Patients Suffering from Advanced Non-small Cell Lung Cancer},
  volume       = {28},
  year         = {2008},
}