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A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer

Lindkvist, Bjorn; Johansen, Dorthe LU ; Borgström, Anders LU and Manjer, Jonas LU (2008) In BMC Cancer 8.
Abstract
Background: The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the association between H. pylori seropositivity and the risk for pancreatic cancer in a nested case-control study within a population based cohort. Methods: Selected birth- year cohorts (born 1921-1949) of residents in Malmo, Sweden, were invited to a health screening investigation. A total of 33 346 subjects participated. Cases with pancreatic cancer (n = 87) were matched to controls (n = 263) using age, sex and time for baseline investigation as matching variables. H. pylori serology was analysed in stored serum samples using... (More)
Background: The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the association between H. pylori seropositivity and the risk for pancreatic cancer in a nested case-control study within a population based cohort. Methods: Selected birth- year cohorts (born 1921-1949) of residents in Malmo, Sweden, were invited to a health screening investigation. A total of 33 346 subjects participated. Cases with pancreatic cancer (n = 87) were matched to controls (n = 263) using age, sex and time for baseline investigation as matching variables. H. pylori serology was analysed in stored serum samples using an enzyme-linked immunosorbent assay. Odds ratios (OR) for pancreatic cancer were calculated with 95% confidence intervals (CI) using logistic regression. Results: H. pylori seropositivity was not associated with pancreatic cancer in the total cohort (adjusted OR 1.25 (0.75-2.09)). However, a statistically significant association was found in never smokers (OR 3.81 (1.06-13.63) adjusted for alcohol consumption) and a borderline statistically significant association was found in subjects with low alcohol consumption (OR 2.13 (0.97-4.69) adjusted for smoking). Conclusion: We conclude that no association between H. pylori infection and the risk for pancreatic cancer was found in the total cohort. However, in never smokers and in subjects with low risk alcohol consumption, a positive H. pylori serology was associated with an increased risk for pancreatic cancer. These findings should be interpreted cautiously due to the limited number of cases in these subgroups. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
8
publisher
BioMed Central
external identifiers
  • wos:000262161200001
  • scopus:58149333433
ISSN
1471-2407
DOI
10.1186/1471-2407-8-321
language
English
LU publication?
yes
id
c387dd59-f1f9-4d85-baa5-36b89d5ea993 (old id 1376260)
date added to LUP
2009-04-24 12:23:01
date last changed
2017-08-27 04:49:42
@article{c387dd59-f1f9-4d85-baa5-36b89d5ea993,
  abstract     = {Background: The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the association between H. pylori seropositivity and the risk for pancreatic cancer in a nested case-control study within a population based cohort. Methods: Selected birth- year cohorts (born 1921-1949) of residents in Malmo, Sweden, were invited to a health screening investigation. A total of 33 346 subjects participated. Cases with pancreatic cancer (n = 87) were matched to controls (n = 263) using age, sex and time for baseline investigation as matching variables. H. pylori serology was analysed in stored serum samples using an enzyme-linked immunosorbent assay. Odds ratios (OR) for pancreatic cancer were calculated with 95% confidence intervals (CI) using logistic regression. Results: H. pylori seropositivity was not associated with pancreatic cancer in the total cohort (adjusted OR 1.25 (0.75-2.09)). However, a statistically significant association was found in never smokers (OR 3.81 (1.06-13.63) adjusted for alcohol consumption) and a borderline statistically significant association was found in subjects with low alcohol consumption (OR 2.13 (0.97-4.69) adjusted for smoking). Conclusion: We conclude that no association between H. pylori infection and the risk for pancreatic cancer was found in the total cohort. However, in never smokers and in subjects with low risk alcohol consumption, a positive H. pylori serology was associated with an increased risk for pancreatic cancer. These findings should be interpreted cautiously due to the limited number of cases in these subgroups.},
  articleno    = {321},
  author       = {Lindkvist, Bjorn and Johansen, Dorthe and Borgström, Anders and Manjer, Jonas},
  issn         = {1471-2407},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer},
  url          = {http://dx.doi.org/10.1186/1471-2407-8-321},
  volume       = {8},
  year         = {2008},
}