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HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine

Joura, Elmar A.; Kjaer, Susanne K.; Wheeler, Cosette M.; Sigurdsson, Kristjan; Iversene, Ole-Erik; Hernandez-Avila, Mauricio; Perez, Gonzalo; Brown, Darron R.; Koutsky, Laura A. and Tay, Eng Hseon, et al. (2008) In Vaccine 26(52). p.6844-6851
Abstract
The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day I and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune... (More)
The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day I and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. (C) 2008 Elsevier Ltd. All rights reserved. (Less)
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keywords
Human Papillomavirus, Humoral immunity, Immune memory
in
Vaccine
volume
26
issue
52
pages
6844 - 6851
publisher
Elsevier
external identifiers
  • wos:000261898400019
  • scopus:56949087305
ISSN
1873-2518
DOI
10.1016/j.vaccine.2008.09.073
language
English
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yes
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00c798d7-5686-4a46-98dc-aee56f4db5cb (old id 1376300)
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2009-04-24 12:46:42
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@article{00c798d7-5686-4a46-98dc-aee56f4db5cb,
  abstract     = {The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day I and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. (C) 2008 Elsevier Ltd. All rights reserved.},
  author       = {Joura, Elmar A. and Kjaer, Susanne K. and Wheeler, Cosette M. and Sigurdsson, Kristjan and Iversene, Ole-Erik and Hernandez-Avila, Mauricio and Perez, Gonzalo and Brown, Darron R. and Koutsky, Laura A. and Tay, Eng Hseon and Garcia, Patricia and Ault, Kevin A. and Garland, Suzanne M. and Leodolter, Sepp and Olssonn, Sven-Eric and Tang, Grace W. K. and Ferris, Daron G. and Paavonen, Jorma and Lehtinen, Matti and Steben, Marc and Bosch, Xavier and Dillner, Joakim and Kurmanv, Robert J. and Majewski, Slawomir and Munoz, Nubia and Myers, Evan R. and Villa, Luisa L. and Taddeo, Frank J. and Roberts, Christine and Tadesse, Amha and Bryan, Janine and Lupinaccia, Lisa C. and Giacoletti, Katherine E. D. and Lu, Shuang and Vuocolo, Scott and Hesley, Teresa M. and Haupt, Richard M. and Barr, Eliav},
  issn         = {1873-2518},
  keyword      = {Human Papillomavirus,Humoral immunity,Immune memory},
  language     = {eng},
  number       = {52},
  pages        = {6844--6851},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2008.09.073},
  volume       = {26},
  year         = {2008},
}