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Vascular Endothelial Growth Factor in Central Nervous System Injuries - A Vascular Growth Factor Getting Nervous?

Skold, Mattias and Kanje, Martin LU (2008) In Current Neurovascular Research 5(4). p.246-259
Abstract
Vascular Endothelial Growth Factor ( VEGF) is recognized as a central factor in growth, survival and permeability of blood vessels in both physiological and pathological conditions. It is as such of importance for vascular responses in various central nervous system (CNS) disorders. Accumulating evidence suggest that VEGF may also act as a neuroprotective and neurotrophic factor supporting neuronal survival and neuronal regeneration. Findings of neuropilins as shared co-receptors between molecules with such seemingly different functions as the axon guidance molecules semaphorins and VEGF has further boosted the interest in the role of VEGF in neural tissue injury and repair mechanisms. Thus, VEGF most likely act in parallel or concurrent... (More)
Vascular Endothelial Growth Factor ( VEGF) is recognized as a central factor in growth, survival and permeability of blood vessels in both physiological and pathological conditions. It is as such of importance for vascular responses in various central nervous system (CNS) disorders. Accumulating evidence suggest that VEGF may also act as a neuroprotective and neurotrophic factor supporting neuronal survival and neuronal regeneration. Findings of neuropilins as shared co-receptors between molecules with such seemingly different functions as the axon guidance molecules semaphorins and VEGF has further boosted the interest in the role of VEGF in neural tissue injury and repair mechanisms. Thus, VEGF most likely act in parallel or concurrent on cells in both the vascular and nervous system. The present review gives a summary of known or potential aspects of the VEGF system in the healthy and diseased nervous system. The potential benefits but also problems and pitfalls in intervening in the actions of such a multifunctional factor as VEGF in the disordered CNS are also covered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Neurovascular Research
volume
5
issue
4
pages
246 - 259
publisher
Bentham Science Publishers
external identifiers
  • wos:000261892900005
  • scopus:56449105358
ISSN
1567-2026
language
English
LU publication?
yes
id
807032f2-92dc-4153-9ab4-a40c61d53b5e (old id 1377466)
date added to LUP
2009-04-24 09:39:31
date last changed
2017-01-01 04:41:44
@article{807032f2-92dc-4153-9ab4-a40c61d53b5e,
  abstract     = {Vascular Endothelial Growth Factor ( VEGF) is recognized as a central factor in growth, survival and permeability of blood vessels in both physiological and pathological conditions. It is as such of importance for vascular responses in various central nervous system (CNS) disorders. Accumulating evidence suggest that VEGF may also act as a neuroprotective and neurotrophic factor supporting neuronal survival and neuronal regeneration. Findings of neuropilins as shared co-receptors between molecules with such seemingly different functions as the axon guidance molecules semaphorins and VEGF has further boosted the interest in the role of VEGF in neural tissue injury and repair mechanisms. Thus, VEGF most likely act in parallel or concurrent on cells in both the vascular and nervous system. The present review gives a summary of known or potential aspects of the VEGF system in the healthy and diseased nervous system. The potential benefits but also problems and pitfalls in intervening in the actions of such a multifunctional factor as VEGF in the disordered CNS are also covered.},
  author       = {Skold, Mattias and Kanje, Martin},
  issn         = {1567-2026},
  language     = {eng},
  number       = {4},
  pages        = {246--259},
  publisher    = {Bentham Science Publishers},
  series       = {Current Neurovascular Research},
  title        = {Vascular Endothelial Growth Factor in Central Nervous System Injuries - A Vascular Growth Factor Getting Nervous?},
  volume       = {5},
  year         = {2008},
}