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Supported liquid membrane work-up of blood plasma samples coupled on-line to liquid chromatographic determination of basic antidepressant drugs

Barri, Thaer LU and Jönsson, Jan Åke LU (2004) In Chromatographia 59(3-4). p.161-165
Abstract
An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL(-1) for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of... (More)
An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL(-1) for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of extraction at three concentrations in the range 40-150 ng mL(-1) for the three drugs was between ca. 3% and 7% as relative standard deviation. The reproducibility relative standard deviation during three different days (replacing the membrane each day) was not significantly higher. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chromatographia
volume
59
issue
3-4
pages
161 - 165
publisher
Vieweg Verlag
external identifiers
  • wos:000224099700003
  • scopus:1442300890
ISSN
0009-5893
DOI
10.1365/s10337-003-0147-y
language
English
LU publication?
yes
id
7812a49d-ecfb-41f3-8127-5808ed85932b (old id 138386)
date added to LUP
2007-06-26 12:44:24
date last changed
2017-01-01 07:25:04
@article{7812a49d-ecfb-41f3-8127-5808ed85932b,
  abstract     = {An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL(-1) for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of extraction at three concentrations in the range 40-150 ng mL(-1) for the three drugs was between ca. 3% and 7% as relative standard deviation. The reproducibility relative standard deviation during three different days (replacing the membrane each day) was not significantly higher.},
  author       = {Barri, Thaer and Jönsson, Jan Åke},
  issn         = {0009-5893},
  language     = {eng},
  number       = {3-4},
  pages        = {161--165},
  publisher    = {Vieweg Verlag},
  series       = {Chromatographia},
  title        = {Supported liquid membrane work-up of blood plasma samples coupled on-line to liquid chromatographic determination of basic antidepressant drugs},
  url          = {http://dx.doi.org/10.1365/s10337-003-0147-y},
  volume       = {59},
  year         = {2004},
}