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Respiratory Disorders In Two Workers Of Customs Depositories Occupationally Exposed To Mouldy Tobacco

Mackiewicz, Barbara; Skorska, Czeslawa; Krysinska-Traczyk, Ewa; Larsson, Lennart LU ; Szponar, Bogumila; Milanowski, Janusz; Czekajska-Chehab, Elzbieta; Sitkowska, Jolanta; Cholewa, Grazyna and Szymanska, Jolanta, et al. (2008) In Annals of Agricultural and Environmental Medicine 15(2). p.317-322
Abstract
Work-related respiratory symptoms, including dyspnoea, cough, fever, tiredness and malaise, were recorded in two customs officers employed in 2 depositories of confiscated cigarettes, of which one showed signs of dampness. Microbiological sampling of the air and the cigarettes stored in a damp depository revealed the presence of potentially pathogenic fungi and bacteria and the biochemical markers of bacterial lipopolysaccharide and fungal biomass. The Penicillium species (P. simplicissimum, P. inflatum, P commune) dominated in the damp depository, while in the other one Aspergillus fumigatus was prevalent. The patients under study did not show a specific sensitization to microbial allergens in the precipitin test, the test for inhibition... (More)
Work-related respiratory symptoms, including dyspnoea, cough, fever, tiredness and malaise, were recorded in two customs officers employed in 2 depositories of confiscated cigarettes, of which one showed signs of dampness. Microbiological sampling of the air and the cigarettes stored in a damp depository revealed the presence of potentially pathogenic fungi and bacteria and the biochemical markers of bacterial lipopolysaccharide and fungal biomass. The Penicillium species (P. simplicissimum, P. inflatum, P commune) dominated in the damp depository, while in the other one Aspergillus fumigatus was prevalent. The patients under study did not show a specific sensitization to microbial allergens in the precipitin test, the test for inhibition of leukocyte migration and the bronchial provocation challenge, except for a weak reaction to fungal allergens in the test for inhibition of leukocyte migration. Moreover, one patient responded with subjective symptoms after exposure to inhalation of increased doses of Penicillium simplicissimum antigen. Both cases were diagnosed as a specific form of organic dust toxic syndrome (ODTS). It is hypothesized that the symptoms were evoked most probably by the non-specific action of low molecular fungal metabolites, such as mycotoxins or VOCs (volatile organic compounds), with the possible contribution of bacterial endotoxin. However, as there is no a direct proof to support this presumption, and the effects of nicotine and other tobacco constituents cannot be excluded, further studies are needed to elucidate etiopathogenesis of the disorders associated with the exposure to stored tobacco. (Less)
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keywords
organic dust toxic syndrome, work-related respiratory symptoms, tobacco, customs depository workers, occupational exposure, bacteria, fungi, bioaerosol
in
Annals of Agricultural and Environmental Medicine
volume
15
issue
2
pages
317 - 322
publisher
Institute of Agricultural Medicine in Lublin, Poland
external identifiers
  • wos:000261767500022
  • scopus:57449114733
ISSN
1898-2263
language
English
LU publication?
yes
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cbc2f4e9-a7c2-41b7-be1d-0257ca4e00aa (old id 1384068)
date added to LUP
2009-05-08 16:26:42
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2017-01-01 05:08:22
@article{cbc2f4e9-a7c2-41b7-be1d-0257ca4e00aa,
  abstract     = {Work-related respiratory symptoms, including dyspnoea, cough, fever, tiredness and malaise, were recorded in two customs officers employed in 2 depositories of confiscated cigarettes, of which one showed signs of dampness. Microbiological sampling of the air and the cigarettes stored in a damp depository revealed the presence of potentially pathogenic fungi and bacteria and the biochemical markers of bacterial lipopolysaccharide and fungal biomass. The Penicillium species (P. simplicissimum, P. inflatum, P commune) dominated in the damp depository, while in the other one Aspergillus fumigatus was prevalent. The patients under study did not show a specific sensitization to microbial allergens in the precipitin test, the test for inhibition of leukocyte migration and the bronchial provocation challenge, except for a weak reaction to fungal allergens in the test for inhibition of leukocyte migration. Moreover, one patient responded with subjective symptoms after exposure to inhalation of increased doses of Penicillium simplicissimum antigen. Both cases were diagnosed as a specific form of organic dust toxic syndrome (ODTS). It is hypothesized that the symptoms were evoked most probably by the non-specific action of low molecular fungal metabolites, such as mycotoxins or VOCs (volatile organic compounds), with the possible contribution of bacterial endotoxin. However, as there is no a direct proof to support this presumption, and the effects of nicotine and other tobacco constituents cannot be excluded, further studies are needed to elucidate etiopathogenesis of the disorders associated with the exposure to stored tobacco.},
  author       = {Mackiewicz, Barbara and Skorska, Czeslawa and Krysinska-Traczyk, Ewa and Larsson, Lennart and Szponar, Bogumila and Milanowski, Janusz and Czekajska-Chehab, Elzbieta and Sitkowska, Jolanta and Cholewa, Grazyna and Szymanska, Jolanta and Dutkiewicz, Jacek},
  issn         = {1898-2263},
  keyword      = {organic dust toxic syndrome,work-related respiratory symptoms,tobacco,customs depository workers,occupational exposure,bacteria,fungi,bioaerosol},
  language     = {eng},
  number       = {2},
  pages        = {317--322},
  publisher    = {Institute of Agricultural Medicine in Lublin, Poland},
  series       = {Annals of Agricultural and Environmental Medicine},
  title        = {Respiratory Disorders In Two Workers Of Customs Depositories Occupationally Exposed To Mouldy Tobacco},
  volume       = {15},
  year         = {2008},
}