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Particle formation and capture during spray drying of inhalable particles

Mosén, Kristina LU ; Bäckström, Kjell; Thalberg, Kyrre; Schaefer, Torben; Kristensen, Henning G and Axelsson, Anders LU (2004) In Pharmaceutical Development and Technology 9(4). p.409-417
Abstract
An investigation of the spray drying process is made in great detail regarding particle formation and capture efficiency with focus on the production of inhalable particles. Mannitol was spray dried as model substance and the spray-dried products were characterized. The resulting products consisted of smooth spheres with a volume median diameter of 2.2-5.5 mum, and narrow size distributions. The investigation was performed in pilot scale of sufficient size to draw general conclusions and make some recommendations. It has been shown that the size of particles is decreased when the feed concentration is decreased, the nozzle gas/feed flow mass ratio increased, and the droplet size decreased. The collection efficiency of the cyclone device... (More)
An investigation of the spray drying process is made in great detail regarding particle formation and capture efficiency with focus on the production of inhalable particles. Mannitol was spray dried as model substance and the spray-dried products were characterized. The resulting products consisted of smooth spheres with a volume median diameter of 2.2-5.5 mum, and narrow size distributions. The investigation was performed in pilot scale of sufficient size to draw general conclusions and make some recommendations. It has been shown that the size of particles is decreased when the feed concentration is decreased, the nozzle gas/feed flow mass ratio increased, and the droplet size decreased. The collection efficiency of the cyclone device used in this study was shown to have a cut-off of 2 mum, i.e., 50% of the particles less than 2 mum are not captured. The data reported indicate that the majority of the single particles formed here, <5 μm, arise from single droplets (of about 10 μm) and are solid, nonporous particles. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmaceutical Development and Technology
volume
9
issue
4
pages
409 - 417
publisher
Taylor & Francis
external identifiers
  • pmid:15581077
  • wos:000225267000008
  • scopus:8744248339
ISSN
1083-7450
DOI
10.1081/PDT-200035795
language
English
LU publication?
yes
id
530915bf-e4af-45ce-a70c-7a6b7dddadaa (old id 138756)
date added to LUP
2007-06-25 13:35:37
date last changed
2017-08-06 04:22:53
@article{530915bf-e4af-45ce-a70c-7a6b7dddadaa,
  abstract     = {An investigation of the spray drying process is made in great detail regarding particle formation and capture efficiency with focus on the production of inhalable particles. Mannitol was spray dried as model substance and the spray-dried products were characterized. The resulting products consisted of smooth spheres with a volume median diameter of 2.2-5.5 mum, and narrow size distributions. The investigation was performed in pilot scale of sufficient size to draw general conclusions and make some recommendations. It has been shown that the size of particles is decreased when the feed concentration is decreased, the nozzle gas/feed flow mass ratio increased, and the droplet size decreased. The collection efficiency of the cyclone device used in this study was shown to have a cut-off of 2 mum, i.e., 50% of the particles less than 2 mum are not captured. The data reported indicate that the majority of the single particles formed here, &lt;5 μm, arise from single droplets (of about 10 μm) and are solid, nonporous particles.},
  author       = {Mosén, Kristina and Bäckström, Kjell and Thalberg, Kyrre and Schaefer, Torben and Kristensen, Henning G and Axelsson, Anders},
  issn         = {1083-7450},
  language     = {eng},
  number       = {4},
  pages        = {409--417},
  publisher    = {Taylor & Francis},
  series       = {Pharmaceutical Development and Technology},
  title        = {Particle formation and capture during spray drying of inhalable particles},
  url          = {http://dx.doi.org/10.1081/PDT-200035795},
  volume       = {9},
  year         = {2004},
}