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Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats.

Lane, Emma LU ; Vercammen, L; Cenci Nilsson, Angela LU and Brundin, Patrik LU (2009) In Experimental Neurology 219. p.355-358
Abstract
In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's disease. The mechanisms underlying these involuntary movements need to be clarified before this approach to clinical cell therapy can be developed further. We previously found that rats with 6-OHDA lesions, primed with L-DOPA treatment and that have subsequently undergone intrastriatal graft surgery exhibit involuntary movements when subjected to amphetamine. This model of amphetamine-induced AIMs reflects a pattern of post-graft behaviors that in the absence of robust spontaneous GID in the rat is the closest approximation that we currently have available. We now show that they are... (More)
In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's disease. The mechanisms underlying these involuntary movements need to be clarified before this approach to clinical cell therapy can be developed further. We previously found that rats with 6-OHDA lesions, primed with L-DOPA treatment and that have subsequently undergone intrastriatal graft surgery exhibit involuntary movements when subjected to amphetamine. This model of amphetamine-induced AIMs reflects a pattern of post-graft behaviors that in the absence of robust spontaneous GID in the rat is the closest approximation that we currently have available. We now show that they are associated with the chronic administration of L-DOPA prior to the transplantation surgery. We also demonstrate that neither changes in c-fos nor FosB/DeltaFosB expression in the lateral striatum are associated with the expression of these behaviours. Taken together, these data reveal that the severity of abnormal movements elicited by amphetamine in grafted animals may relate to previous L-DOPA exposure and dyskinesia development, but they develop through mechanisms that are independent of FosB/DeltaFosB upregulation. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
219
pages
355 - 358
publisher
Academic Press
external identifiers
  • wos:000269398600041
  • pmid:19393238
  • scopus:68549099660
ISSN
0014-4886
DOI
10.1016/j.expneurol.2009.04.010
language
English
LU publication?
yes
id
0de122a4-132d-4dd6-9a22-91479434841f (old id 1391837)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19393238?dopt=Abstract
date added to LUP
2009-05-05 14:57:08
date last changed
2017-04-09 04:28:36
@article{0de122a4-132d-4dd6-9a22-91479434841f,
  abstract     = {In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's disease. The mechanisms underlying these involuntary movements need to be clarified before this approach to clinical cell therapy can be developed further. We previously found that rats with 6-OHDA lesions, primed with L-DOPA treatment and that have subsequently undergone intrastriatal graft surgery exhibit involuntary movements when subjected to amphetamine. This model of amphetamine-induced AIMs reflects a pattern of post-graft behaviors that in the absence of robust spontaneous GID in the rat is the closest approximation that we currently have available. We now show that they are associated with the chronic administration of L-DOPA prior to the transplantation surgery. We also demonstrate that neither changes in c-fos nor FosB/DeltaFosB expression in the lateral striatum are associated with the expression of these behaviours. Taken together, these data reveal that the severity of abnormal movements elicited by amphetamine in grafted animals may relate to previous L-DOPA exposure and dyskinesia development, but they develop through mechanisms that are independent of FosB/DeltaFosB upregulation.},
  author       = {Lane, Emma and Vercammen, L and Cenci Nilsson, Angela and Brundin, Patrik},
  issn         = {0014-4886},
  language     = {eng},
  pages        = {355--358},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats.},
  url          = {http://dx.doi.org/10.1016/j.expneurol.2009.04.010},
  volume       = {219},
  year         = {2009},
}