Advanced

Scavenger receptors: role in innate immunity and microbial pathogenesis.

Areschoug, Thomas LU and Gordon, Siamon (2009) In Cellular Microbiology 11. p.1160-1169
Abstract
Summary Accumulating evidence shows that many scavenger receptors (SR), including SR-A, MARCO and CD36, represent an important part of the innate immune defence by acting as pattern-recognition receptors (PRR), in particular against bacterial pathogens. Several SR are expressed on macrophages and dendritic cells, where they act as phagocytic receptors mediating non-opsonic phagocytosis of pathogenic microbes. Another important function of some SR is to act as co-receptors to TLRs, modulating the inflammatory response to TLR agonists. On bacteria, the SR ligands have commonly been reported to be LPS and LTA, but recent advances in the field indicate that bacterial surface proteins play a more important role as target molecules for SR than... (More)
Summary Accumulating evidence shows that many scavenger receptors (SR), including SR-A, MARCO and CD36, represent an important part of the innate immune defence by acting as pattern-recognition receptors (PRR), in particular against bacterial pathogens. Several SR are expressed on macrophages and dendritic cells, where they act as phagocytic receptors mediating non-opsonic phagocytosis of pathogenic microbes. Another important function of some SR is to act as co-receptors to TLRs, modulating the inflammatory response to TLR agonists. On bacteria, the SR ligands have commonly been reported to be LPS and LTA, but recent advances in the field indicate that bacterial surface proteins play a more important role as target molecules for SR than previously thought. Interestingly, recent data show that major pathogens, including Streptococcus pyogenes and the group B streptococcus (GBS), have evolved mechanisms to evade SR-mediated recognition. Moreover, intracellular pathogens, such as hepatitis C virus (HCV) and Plasmodium falciparum, utilize the SR to gain entry into host cells, focusing interest on the importance of SR also in the molecular pathogenesis of infectious diseases. This review highlights the complex interactions between SR and pathogenic microbes, and discusses the role of these interactions in host defence and microbial pathogenesis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular Microbiology
volume
11
pages
1160 - 1169
publisher
Wiley-Blackwell
external identifiers
  • wos:000267658300002
  • pmid:19388903
  • scopus:67650102353
ISSN
1462-5814
DOI
10.1111/j.1462-5822.2009.01326.x
language
English
LU publication?
yes
id
d55fc977-ffe9-4c72-8dcc-ffe8faf3c66a (old id 1391906)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19388903?dopt=Abstract
date added to LUP
2009-05-05 15:43:23
date last changed
2017-11-12 04:06:48
@article{d55fc977-ffe9-4c72-8dcc-ffe8faf3c66a,
  abstract     = {Summary Accumulating evidence shows that many scavenger receptors (SR), including SR-A, MARCO and CD36, represent an important part of the innate immune defence by acting as pattern-recognition receptors (PRR), in particular against bacterial pathogens. Several SR are expressed on macrophages and dendritic cells, where they act as phagocytic receptors mediating non-opsonic phagocytosis of pathogenic microbes. Another important function of some SR is to act as co-receptors to TLRs, modulating the inflammatory response to TLR agonists. On bacteria, the SR ligands have commonly been reported to be LPS and LTA, but recent advances in the field indicate that bacterial surface proteins play a more important role as target molecules for SR than previously thought. Interestingly, recent data show that major pathogens, including Streptococcus pyogenes and the group B streptococcus (GBS), have evolved mechanisms to evade SR-mediated recognition. Moreover, intracellular pathogens, such as hepatitis C virus (HCV) and Plasmodium falciparum, utilize the SR to gain entry into host cells, focusing interest on the importance of SR also in the molecular pathogenesis of infectious diseases. This review highlights the complex interactions between SR and pathogenic microbes, and discusses the role of these interactions in host defence and microbial pathogenesis.},
  author       = {Areschoug, Thomas and Gordon, Siamon},
  issn         = {1462-5814},
  language     = {eng},
  pages        = {1160--1169},
  publisher    = {Wiley-Blackwell},
  series       = {Cellular Microbiology},
  title        = {Scavenger receptors: role in innate immunity and microbial pathogenesis.},
  url          = {http://dx.doi.org/10.1111/j.1462-5822.2009.01326.x},
  volume       = {11},
  year         = {2009},
}